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Subject: Application Note: Kinetic Degradation Profiling of IMiD Molecular
 Glues and their Target Families
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Application Note

Kinetic Degradation of IMiD Molecular Glues and Their Target Families

Targeted protein degradation of disease-causing proteins has proven to be a=
 powerful therapeutic approach. The ability to monitor the specificity of d=
egradation amongst related target classes at endogenous protein levels, con=
tinuously in live cells, is critical for understanding the efficacy and mec=
hanism of these compounds.

Figure 1. HiBiT protein-tagging technology. The genomic locus encoding the =
protein of interest can be tagged by homology-directed repair using Cas9 ri=
bonucleoprotein (RNP) in combination with an ssODN repair template. The tag=
ged protein can be detected either in a lytic end-point assay or by coexpre=
ssing LgBiT in live cells.

This application note shows the automation of parallel degradation and viab=
ility screening of several key immunomodulatory drug (IMiD) molecular glue =
targets, IKZF1 (Ikaros), GSPT1, and IKZF2 (Helios) with various IMiDs using=
 the Promega Nano-Glo HiBiT technology, in conjunction with the Agilent Bio=
Tek BioSpa 8 automated incubator (https://email.labxmediagroup.com/e3t/Ctc/=
LT+113/c3tLW04/VVKZsS4GT2pmW12Drd72WHxwrW2lg-cV4J-BkrN1YBnv97cGSrV5X_Kf7CgY=
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and the Agilent BioTek Synergy Neo2 (https://email.labxmediagroup.com/e3t/C=
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99kJYsfW31jcCK258RMTW8S2F5p2DTWR6W5mCBpZ9dx47LW52QwXm6KBwSWW1G9Vxw79bWYXW1f=
S4NP6Vm-3zW31RHVJ2Knw9Y32ZV1 ) hybrid multimode reader.

Download App Note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/=
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jW2cXyhR1mWCXyN2HhXZwHyD3z33Ym1 )

Learn more about the instrumentation in this application note.

Synergy Neo2 Microplate Reader

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ZV1 )

BioSpa 8 Automated Incubator

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2sG1 )

New Applications

Browse our growing list of timely applications and see how Agilent BioTek i=
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0pt; width:100%; max-width:680px; direction:ltr; -ms-text-size-adjust:100%;=
 -webkit-text-size-adjust:100%; border-spacing:0 !important; border-collaps=
e:collapse !important; table-layout:fixed !important; margin:0 auto !import=
ant">
                <tbody style=3D"-ms-text-size-adjust: 100%;-webkit-text-siz=
e-adjust: 100%;"><tr class=3D"top-hero-text" style=3D"-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;">
                  <th class=3D"hero-text-1" width=3D"100%" style=3D"text-al=
ign: left;padding: 10px 20px 0px 20px;color: #ffffff;font-size: 12px;font-f=
amily: Helvetica, Arial, sans-serif;font-weight: normal;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;"><span style=3D"font-size: 18px;-ms=
-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: inherit;" dat=
a-mce-style=3D"font-size: 16px;">Application Note</span></th></tr>
                <tr class=3D"bottom-hero-text" style=3D"-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
                  <td colspan=3D"1" style=3D"mso-table-lspace:0pt; mso-tabl=
e-rspace:0pt; text-align:left; padding:15px 20px 15px 20px; color:#ffffff; =
font-size:32px; font-family:Helvetica, Arial, sans-serif; line-height:1em; =
-ms-text-size-adjust:100%; -webkit-text-size-adjust:100%" align=3D"left"><s=
pan style=3D"font-size: 28px;-ms-text-size-adjust: 100%;-webkit-text-size-a=
djust: 100%;color: inherit;line-height: 1em;" data-mce-style=3D"font-size: =
24px;">Kinetic Degradation of IMiD Molecular Glues and Their Target Familie=
s</span><br style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 1=
00%;"></td>
                </tr></tbody></table>
            </th></tr></tbody>
        </table>
        
      </div>
      
    </center>
    
                      <center class=3D"alt-bg-color" style=3D"background-co=
lor: #e7e7e6;width: 100%;-ms-text-size-adjust: 100%;-webkit-text-size-adjus=
t: 100%;">
                        
                        <div class=3D"email-width" style=3D"padding-bottom:=
 50px;padding-top: 40px;-ms-text-size-adjust: 100%;-webkit-text-size-adjust=
: 100%;margin: 0 auto;max-width: 680px;">
                          
                          <table align=3D"center" width=3D"100%" cellpaddin=
g=3D"0" cellspacing=3D"0" border=3D"0" style=3D"mso-table-lspace:0pt; mso-t=
able-rspace:0pt; width:100%; max-width:680px; -ms-text-size-adjust:100%; -w=
ebkit-text-size-adjust:100%; border-spacing:0 !important; border-collapse:c=
ollapse !important; table-layout:fixed !important; margin:0 auto !important=
">
                            <tbody style=3D"-ms-text-size-adjust: 100%;-web=
kit-text-size-adjust: 100%;">
                            <tr style=3D"-ms-text-size-adjust: 100%;-webkit=
-text-size-adjust: 100%;">
                              <td style=3D"mso-table-lspace:0pt; mso-table-=
rspace:0pt; padding:0px 20px 0px 20px; font-size:.9em; font-family:Helvetic=
a, Arial, sans-serif; line-height:1.7em; color:#53565a; -ms-text-size-adjus=
t:100%; -webkit-text-size-adjust:100%"><p style=3D"margin-bottom: 1em; -ms-=
text-size-adjust:100%; -webkit-text-size-adjust:100%">Targeted protein degr=
adation of disease-causing proteins has proven to be a powerful therapeutic=
 approach. The ability to monitor the specificity of degradation amongst re=
lated target classes at endogenous protein levels, continuously in live cel=
ls, is critical for understanding the efficacy and mechanism of these compo=
unds.</p><p style=3D"margin-bottom: 1em; -ms-text-size-adjust:100%; -webkit=
-text-size-adjust:100%">
</p><center style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 1=
00%;width: 100%;"><img class=3D"col-66" src=3D"https://image.explore.agilen=
t.com/EloquaImages/clients/Agilent/{28f06258-04af-4e43-939a-9eebcef0b80a}_F=
igure-1-500x255.jpg" style=3D"vertical-align:bottom; -ms-interpolation-mode=
:bicubic; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%; width:1=
00%; min-width:460px; max-width:460px; height:auto; display:block; min-heig=
ht:4px" height=3D"auto"></center><p style=3D"margin-bottom: 1em; -webkit-te=
xt-size-adjust:100%; -ms-text-size-adjust:100%"></p>
<p style=3D"margin-bottom: 1em; padding:0px 25px 0px 25px; -ms-text-size-ad=
just:100%; -webkit-text-size-adjust:100%"><span style=3D"font-size: 10px;li=
ne-height: 12px;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;"=
><em style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">F=
igure 1. HiBiT protein-tagging technology. The genomic locus encoding the p=
rotein of interest can be tagged by homology-directed repair using Cas9 rib=
onucleoprotein (RNP) in combination with an ssODN repair template. The tagg=
ed protein can be detected either in a lytic end-point assay or by coexpres=
sing LgBiT in live cells.</em></span></p>
<p style=3D"margin-bottom: 1em; -ms-text-size-adjust:100%; -webkit-text-siz=
e-adjust:100%">This application note shows the automation of parallel degra=
dation and viability screening of several key immunomodulatory drug (IMiD) =
molecular glue targets, IKZF1 (Ikaros), GSPT1, and IKZF2 (Helios) with vari=
ous IMiDs using the Promega Nano-Glo HiBiT technology, in conjunction with =
the <a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VVKZ=
sS4GT2pmW12Drd72WHxwrW2lg-cV4J-BkrN1YBnv97dvPJV5X_Kf7CgLJBW4H6nmS46Xm7tW1f5=
PVn4SKn41W2P_Ccz4pW_1sVD9Bqb6BgQMTW67zGls74m39CVTZFlc8V_Zd6W4KWjnt8XDVJnW1l=
_3np3zfBPKW37fVN43_xJg-W1lJXC_26W76VW5BFzwT1Vfv0_N43mYXM3xRtlN8B4_BQ1Nv5JW8=
W9MJf4prDN6W2z2wQq6d3GpvW6-h_jf43K69zW8gMvGL7X6DsqN4Q-y9HSw3j0W3jXR_N35ldqF=
W3WVNlt3vjkxzW9lf5pH6zP4VgW5TFvdq3hrCZ-N7XS3GvnXtLPW2_wcH37l0DMCVfTr4S3Z9NB=
_W63phFb4JptvKW3vjjzh3_PXkvW4x5ggX76xmbcW9f0tMR5vBGn_W6RyJ-r6CL1sxW5r-V208_=
X5xFTPyJj1ZmVWZV8YnWn4MMGchW8kSvjZ28wlLrW4kLRW83kg9cTW8hD1MY7lKtBPW6WJtk05C=
8nTJW5SjBgQ6-w9C1W27Ck6V2LChKdW1qvHMj4LY68kW489gKp5P8YLRVQn00Y92Ywq6W5XDDF1=
3tKl-5W41whjk4z-bTnW177JRH2qgNYPW7z8_X09m1CwgW3wvD0w1pPvy8N3RxX2cZcMJqW19Bd=
224VZsMxW9306sZ9fJC4_W2Dkchs6LFWq1W2ty4511gBYGFW1k2D2F41xQNpN7Pv_qLq62ry346=
F1" class=3D"textlinks" target=3D"_blank" style=3D"color:#0085d5; text-deco=
ration:none; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%" data=
-hs-link-id=3D"0">Agilent BioTek BioSpa 8 automated incubator</a>
 and the <a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04=
/VVKZsS4GT2pmW12Drd72WHxwrW2lg-cV4J-BkrN1YBnv97dvPJV5X_Kf7CgDQSW84jsQj6mtN3=
JW7KrGfp3zlsQCW2Qqdg76hYqDqW1RQ8sl39X-wLMxJTyH29-6tVs2qGM4bwvjqVztQKg3NnCQB=
W6J_Bn43WkvJzW12bQzy5FhqlPW7y09j_1_ZGJTW3X84Rb6wq8JBV5FlnB1YMFzZN6sCqw5-tm6=
tVMzrXF34y35jW49xJSS5ndK_rW8PHS8s5MYP2MW1GZs9d1mktnkW5ZWzqH1NqvSDVPbKTB38WX=
PTVTHVh88gNsbRW4s5k_14Xtz53W99T5zd7rWlCgW7LBKN93jQChxW2LP-0_1vCZjCN5BXnlG7v=
dpxVmVk0T4gTjVpW3y5yQ34hGmpYN2Xwk-CbZQb8W57nyx-7mg9WjW21LZLT8fvR2QW2JCWQw7-=
YGVWW4D6WTQ7ZqKy4N7Dy95br6ClDW7l5scb8FxRl2W8sfGwZ1Vq19ZW8TGjzS1vs5NrW3VdCS_=
8360hYW1-3k7Y5wlRPKW2HGpQ67GhFcMW3pcsx153CvMbW6Kn0md8SY4ZJW22xyVP3xRs6bN5t0=
DrQ23Jg6W34QvJk5g1HZCW1z9Xvq7fk1K-W4l-lQR5ybp2tW2hCjyY2wz3XwW2QfNwH65gcfDW1=
S5hzH28rDKXW5-X8DB3vyvvLW3g40GN3Wz3YyW7qChDY5zw7n0W3GZmb03F9QJSW4bZpz62XJ4k=
g3jjg1" class=3D"textlinks" target=3D"_blank" style=3D"color:#0085d5; text-=
decoration:none; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%" =
data-hs-link-id=3D"0">Agilent BioTek Synergy Neo2</a> hybrid multimode read=
er.</p>
                            </td></tr>
                          </tbody></table>
                          <table cellpadding=3D"0" cellspacing=3D"0" border=
=3D"0" width=3D"100%" style=3D"mso-table-lspace:0pt; mso-table-rspace:0pt; =
-ms-text-size-adjust:100%; -webkit-text-size-adjust:100%; border-spacing:0 =
!important; border-collapse:collapse !important; table-layout:fixed !import=
ant; margin:0 auto !important"><tbody style=3D"-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><tr style=3D"-ms-text-size-adjust: 100%;-we=
bkit-text-size-adjust: 100%;"><td valign=3D"middle" align=3D"center" class=
=3D"btnAgilent" style=3D"mso-table-lspace:0pt; mso-table-rspace:0pt; paddin=
g-top:20px; padding-bottom:0px; -ms-text-size-adjust:100%; -webkit-text-siz=
e-adjust:100%">
<a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VVKZsS4G=
T2pmW12Drd72WHxwrW2lg-cV4J-BkrN1YBntB7dvP5V5X_Kf7CgZJxW704s9Q6Dzbw2V5mldm3m=
C2kBW7B8Rkp8csqbPW3gMqZv2Yc4bZW54X2Sb3NW0q_W5ShZ0v2F7c4lW2V-j2n3WGCW7W4qdLg=
Z7x1ttsN5-BqdjwNsJmW6nJ8cb1HnR3sW1BdMrm2mKhpyVYbp7L79lB5tW4X2R8N40pCC1W1x-M=
lJ7pQhMfW10psqN7sbrg_W6SJm8y1TVFJwVR-3rm5vrmC4W1Jln7s1pk24TW7MZKSH4-NZKhW3n=
WKFJ3mFzQ9W1z8F9x22NJqfW6vk8bP1d7-cJW31Dm4r8VsJnlW4zhNPr5yH8xRVFg2G03yNqGyW=
1tT9L892MV4GV-W8Wc34zMKMVjkWsp4jJmrvW2TPD6m4jj3GdN7FNNTjbs4MKW2d6szj63LDBMW=
5-74XS8XHM1BW7cRLWw7xQGtKW2FWyRC5YWlBxW69mbn-8Lrb-3W4klsS47gKpF7W3SrzqW7Hqm=
84W50krxC2qw-76W6sMGH37lRKmXN441680y-WqDW8bYcJf8qB62YW49z7w-50XhcyW3gMM5798=
6FHpW2ftgvM42X25NW4Yft722qQ4ZCW4z4p8-3MxGJNW5rKpVs70KmlLN9kXm6q8sFJJW5b5dQp=
68KyQWW2-KtrV83bJHg3mFp1" target=3D"_blank" style=3D"background-color:#0085=
d5; text-decoration:none; color:#fff; display:inline-block; border-top:10px=
 solid #0085d5; border-right:20px solid #0085d5; border-bottom:10px solid #=
0085d5; border-left:20px solid #0085d5; text-align:center; font-family:Helv=
etica, Arial, sans-serif; font-size:11px; font-weight:normal; line-height:1=
00%; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%" title=3D"" b=
gcolor=3D"#0085d5" align=3D"center" data-hs-link-id=3D"0">Download App Note=
</a></td></tr></tbody></t=
able>
                          
                        </div>
                        
                      </center>
                      
                      <center class=3D"alt-bg-color" style=3D"background-co=
lor: #d9d9d8;width: 100%;-ms-text-size-adjust: 100%;-webkit-text-size-adjus=
t: 100%;">
                        
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m: 50px;padding-top: 40px;-ms-text-size-adjust: 100%;-webkit-text-size-adju=
st: 100%;margin: 0 auto;max-width: 680px;">
                            
                            <div class=3D"section-callout" style=3D"-ms-tex=
t-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                              <table align=3D"center" width=3D"100%" cellpa=
dding=3D"0" cellspacing=3D"0" border=3D"0" style=3D"mso-table-lspace:0pt; m=
so-table-rspace:0pt; width:100%; max-width:680px; -ms-text-size-adjust:100%=
; -webkit-text-size-adjust:100%; border-spacing:0 !important; border-collap=
se:collapse !important; table-layout:fixed !important; margin:0 auto !impor=
tant">
                                <tbody style=3D"-ms-text-size-adjust: 100%;=
-webkit-text-size-adjust: 100%;">
                                  <tr style=3D"-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><td align=3D"left" style=3D"mso-table-lspac=
e:0pt; mso-table-rspace:0pt; padding:0px 20px 20px 20px; font-size:1.3em; f=
ont-family:Helvetica, Arial, sans-serif; color:#000000; text-align:left; -m=
s-text-size-adjust:100%; -webkit-text-size-adjust:100%">Learn more about th=
e instrumentation in this application note.</td></tr>
                                </tbody>
                              </table>
                              <table align=3D"center" width=3D"100%" cellpa=
dding=3D"0" cellspacing=3D"0" border=3D"0" style=3D"mso-table-lspace:0pt; m=
so-table-rspace:0pt; width:100%; max-width:680px; -ms-text-size-adjust:100%=
; -webkit-text-size-adjust:100%; border-spacing:0 !important; border-collap=
se:collapse !important; table-layout:fixed !important; margin:0 auto !impor=
tant">
                              <tbody style=3D"-ms-text-size-adjust: 100%;-w=
ebkit-text-size-adjust: 100%;">
                                <tr style=3D"-ms-text-size-adjust: 100%;-we=
bkit-text-size-adjust: 100%;"><th class=3D"col-50" width=3D"330" valign=3D"=
top" style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;fon=
t-weight: normal;width: 330px;min-width: 330px;max-width: 330px;">
                                  <table align=3D"center" width=3D"100%" ce=
llpadding=3D"0" cellspacing=3D"0" border=3D"0" style=3D"mso-table-lspace:0p=
t; mso-table-rspace:0pt; width:100%; max-width:100%; -ms-text-size-adjust:1=
00%; -webkit-text-size-adjust:100%; border-spacing:0 !important; border-col=
lapse:collapse !important; table-layout:fixed !important; margin:0 auto !im=
portant">
                                    <tbody style=3D"-ms-text-size-adjust: 1=
00%;-webkit-text-size-adjust: 100%;"><tr style=3D"-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
                                      <td style=3D"mso-table-lspace:0pt; ms=
o-table-rspace:0pt; padding:0px 20px 0px 20px; -ms-text-size-adjust:100%; -=
webkit-text-size-adjust:100%" class=3D"callout-mobile-padding-image">
                                        <table align=3D"center" width=3D"10=
0%" cellpadding=3D"0" cellspacing=3D"0" border=3D"0" style=3D"mso-table-lsp=
ace:0pt; mso-table-rspace:0pt; width:100%; max-width:100%; background-color=
:#ffffff; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%; border-=
spacing:0 !important; border-collapse:collapse !important; table-layout:fix=
ed !important; margin:0 auto !important" bgcolor=3D"#ffffff">
                                          <tbody style=3D"-ms-text-size-adj=
ust: 100%;-webkit-text-size-adjust: 100%;"><tr style=3D"-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
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o-table-lspace:0pt; mso-table-rspace:0pt; background-color:#0085d5; line-he=
ight:4px; font-size:4px; -ms-text-size-adjust:100%; -webkit-text-size-adjus=
t:100%" bgcolor=3D"#0085d5"><img src=3D"https://image.explore.agilent.com/E=
loquaImages/clients/Agilent/{aa278086-f981-4fcd-97fe-c05cbc17644d}_20170518=
-edm-teaser.png" width=3D"300" height=3D"auto" border=3D"0" alt=3D"" role=
=3D"presentation" style=3D"vertical-align:bottom; -ms-interpolation-mode:bi=
cubic; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%; height:aut=
o; width:100%; display:block; min-height:4px"></td>
                                          </tr>
                                          <tr style=3D"-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;">
                                            <td class=3D"callout-mobile-pad=
ding-image" style=3D"mso-table-lspace:0pt; mso-table-rspace:0pt; padding:20=
px 20px 10px 20px; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%=
"><img src=3D"https://image.explore.agilent.com/EloquaImages/clients/Agilen=
t/{fb25b381-ff33-4a9f-9e3b-6cd71b020de7}_XB-Synergy-Neo2-center-closed_260x=
146.png" alt=3D"Synergy neo2" width=3D"100%" style=3D"vertical-align:bottom=
; -ms-interpolation-mode:bicubic; -ms-text-size-adjust:100%; -webkit-text-s=
ize-adjust:100%; height:auto; width:100%; display:block; min-height:4px" he=
ight=3D"auto"></td>
                                          </tr>
                                          <tr style=3D"-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;">
                                            <td style=3D"mso-table-lspace:0=
pt; mso-table-rspace:0pt; padding:10px 20px 10px 20px; text-align:left; fon=
t-weight:normal; font-size:.9em; font-family:Helvetica, Arial, sans-serif; =
line-height:1.8em; color:#53565a; -ms-text-size-adjust:100%; -webkit-text-s=
ize-adjust:100%" align=3D"left">
                                              <div class=3D"callout-mobile-=
padding-2" style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 10=
0%;">
                                                <div style=3D"font-size: 1.=
2em;font-family: Helvetica, Arial, sans-serif;color: #000000;-ms-text-size-=
adjust: 100%;-webkit-text-size-adjust: 100%;">Synergy Neo2 Microplate Reade=
r</div>
                                               =20
                                                =20
                                               =20
                                                <table cellpadding=3D"0" ce=
llspacing=3D"0" border=3D"0" width=3D"100%" style=3D"mso-table-lspace:0pt; =
mso-table-rspace:0pt; -ms-text-size-adjust:100%; -webkit-text-size-adjust:1=
00%; border-spacing:0 !important; border-collapse:collapse !important; tabl=
e-layout:fixed !important; margin:0 auto !important"><tbody style=3D"-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;"><tr style=3D"-ms-text=
-size-adjust: 100%;-webkit-text-size-adjust: 100%;"><td valign=3D"middle" a=
lign=3D"center" class=3D"btnAgilent" style=3D"mso-table-lspace:0pt; mso-tab=
le-rspace:0pt; padding-top:20px; padding-bottom:20px; -ms-text-size-adjust:=
100%; -webkit-text-size-adjust:100%">
<a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VVKZsS4G=
T2pmW12Drd72WHxwrW2lg-cV4J-BkrN1YBnv97dvPJV5X_Kf7CgTfLW7N-1tK7pbswwN8z74mqV=
T1CpW1DQ5PN7kNnyRW1PwY3p254HzGW3jbbrz4y2M_bW1LM0xH4S0ShDW1fv-rq670k3bW6v25-=
q4GYmsQW6z3FN582cglRW7jrj4M8K9yp5W2rVtZS5_GWb6W7WpRXQ7MXfgqW1LRYmV2mtFJRW1R=
cQCh5N5cVgW95p39G8DsyHCW4Vv6Dn33rZH9Vnhwcw4Tlp5cW8MHF3x3PqmJZW6rz6Gz4kDxbWW=
59tfwb23BkTDW8KK_z25m5-NXW8vbltn8FcKvBW1FF1Kt5-hk8hN5XZf-g8NbLHW12tyjD6TM81=
vV-wjGr2PDGMXW8Z96nG6JKcqFW7rZX0R52wFDgN5jGCKKXDK6wV6PRtB6XNbqYW2BbzwW6S2x1=
XW6vP6N58B8srxW51vzF855R2rPW44Mvkl3BmXkCW8DFKd86MQJ4bW4yN3Ky5VHhFSW70qS0q16=
YKwSW7qtt4x1-tVSrW1Pvgy73vgNQ8N71HgbG1NpppW3ZZvJh3tNJrqW5SjXwx7XT8N0W7JbClV=
4gmmvGW4ls9l05HrDFrVKRDH72-SbsgW4XChqG33_7xGW93zMrW8s4v9HV-MMpj3tTF6HW5k5Gf=
F3Vyg9TN3B-f4xldLQRN7SYcgxV65W7W8kBTDW8jC1BnN74_6w14BVN_VjhnX41Ffq2v38r41" =
target=3D"_blank" style=3D"background-color:#0085d5; text-decoration:none; =
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t/{c8c5f117-a7d7-4e82-bfc7-dbee208fae3c}_XB-BioSpa8_260x146.png" alt=3D"Bio=
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auto; width:100%; display:block; min-height:4px" height=3D"auto"></td>
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                                                    <p style=3D"margin-bott=
om: 1em; -ms-text-size-adjust:100%; -webkit-text-size-adjust:100%">Browse o=
ur growing list of timely applications and see how Agilent BioTek instrumen=
tation can facilitate even the most complex workflows.</p>
                                                    <table cellpadding=3D"0=
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7qkyn55rbFDn3q0h1" target=3D"_blank" style=3D"background-color:#0085d5; tex=
t-decoration:none; color:#fff; display:inline-block; border-top:10px solid =
#0085d5; border-right:20px solid #0085d5; border-bottom:10px solid #0085d5;=
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--[if gte mso 12]></td></tr>
</table><![endif]--></td></tr></tbody></table>
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