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Envelope-to: pamay@sapasequipment.com
Delivery-date: Mon, 19 Sep 2022 13:04:53 -0400
Date: Mon, 19 Sep 2022 10:04:10 -0700
From: Molecular Devices <info@moldev.com>
Reply-To: info@moldev.com
To: pamay@sapasequipment.com
Message-ID: <1663606831791.4e01dd77-722c-40b0-8104-aaa58698b984@bf08x.hubspotemail.net>
Subject: Rapidly assess drug response in 3D breast cancer models
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Rapidly assess cell viability in 3D cultures

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NEW

Application Spotlight

Rapidly assess drug response in breast cancer models

For many years, two-dimensional (2D) cell culture involving cells grown in =
a monolayer on a flat culture surface has served as a convenient system for=
 investigating disease mechanisms and assessing the effects of potential ne=
w drugs. Cancer cell lines grown in 2D have long served as experimental sur=
rogates for the cancers from which they were derived. In recent years, the =
culture of cancer cells, along with other cell types, in three-dimensional =
(3D) formats where they can form multi-layered structures is enabling new m=
odels for cancer research that are considered more biologically relevant.

In this application note, we demonstrate how our SpectraMax=C2=AE iD5 Multi=
-Mode Microplate Reader can provide:

- Rapid assessment of cell viability in 3D cultures
- Highly sensitive luminescent readout
- Easy 3D cell culture and assay setup in U-bottom microplates

Learn more:
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<div id=3D"column-5-0" class=3D"hse-column hse-size-12">
  <table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D=
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table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
style=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-famil=
y:Arial, sans-serif; font-size:14px; color:#6a747c; word-break:break-word; =
padding:10px 35px 26px"><div id=3D"hs_cos_wrapper_module_16630898609522" cl=
ass=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" sty=
le=3D"color: inherit; font-size: inherit; line-height: inherit;" data-hs-co=
s-general-type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wra=
pper_module_16630898609522_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget =
hs_cos_wrapper_type_rich_text" style=3D"color: inherit; font-size: inherit;=
 line-height: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-typ=
e=3D"rich_text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; line-h=
eight:150%; font-size:22px; color:#75ac58; font-family:'ProximaNova', Arial=
, sans-serif">NEW</h1>
<h2 style=3D"margin:0; mso-line-height-rule:exactly; line-height:150%; font=
-size:16px; color:#3692ab; font-family:'ProximaNova', Arial, sans-serif">Ap=
plication Spotlight</h2>
<p style=3D"mso-line-height-rule:exactly; line-height:150%">&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; line-height:150%; font-weight:bol=
d; font-family:'ProximaNova', Arial, sans-serif"><span style=3D"color: #000=
000;">Rapidly assess drug response in breast cancer models</span></p>
<p style=3D"mso-line-height-rule:exactly; line-height:100%">&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; line-height:150%">For many years,=
 two-dimensional (2D) cell culture involving cells grown in a monolayer on =
a flat culture surface has served as a convenient system for investigating =
disease mechanisms and assessing the effects of potential new drugs. Cancer=
 cell lines grown in 2D have long served as experimental surrogates for the=
 cancers from which they were derived. In recent years, the culture of canc=
er cells, along with other cell types, in three-dimensional (3D) formats wh=
ere they can form multi-layered structures is enabling new models for cance=
r research that are considered more biologically relevant.</p>
<p style=3D"mso-line-height-rule:exactly; line-height:150%">&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; line-height:150%">In this <span s=
tyle=3D"color: #75ac34;"><a href=3D"https://email.moleculardevices.com/e3t/=
Ctc/OR+113/d2nr5L04/VVZBgp4mHxWCW6sfTdY62C93ZW4Rs6st4Q7Gm-N6pj1VV7dvNQV5X_K=
f7CgZMbW7dpq7N1fj0GfW11z5P64cVqkcW8Dpx1k5yg0ljW4RTbQv6LtvlDW26vnkm4dmhLjW1_=
rmCB90ktygW2-nB0k3TRStLVpNplm6VGHhpW76ck2q6C3LN0W4JfLyc7HmbGqW4DDfZ-2jWS1hV=
LdkNf4ds9VTVKxKw47YVrpnV2DVTv2FpYnWVQQT7q1LTSb4W4BjFlC8JTYkpW7LRQyD2ZzhlvW6=
sVQ5z2n2nTmN9gfBhw2xSRCW8qhkg745vBqvW8Sb-KL4XkJM8W5ndCF27mM-W3W7HMMv94V8xyx=
W5nxwzb2KwyY2W830hGn6bFjjcVsP_VC6mX1vYW96xgFF3BGN8yN4V-Gdk97GFLW1Q7wV28mfML=
2N6-tdDzSQfLfW4Ln5Zk82NHszV8_ZZX96V1ypW7bSlNB6kXMw0N8V4hhkP6GbQW1fnrY92fdnV=
3W3KWf653R71NCW3myjjh8-qDg0W7cWNBg7lDJkCN6SNdBRjxZ0ZW4cLddD1QBtn_W5PY3vd2XZ=
64WW4H95W94SqLrLW3MXMQT14K438W7246W27JHXxBW1mfYpw2hZTcZW8Qdx1f8-Sm26VFqwMp8=
2TpfKN4CcNpJwxt0r32mN1" style=3D"mso-line-height-rule:exactly; text-decorat=
ion:none; font-weight:bold; color:#75ac34" rel=3D"noopener" data-hs-link-id=
=3D"1" target=3D"_blank">application note</a></span>, we demonstrate how ou=
r SpectraMax=C2=AE iD5 Multi-Mode Microplate Reader can provide:</p>
<ul style=3D"mso-line-height-rule:exactly; line-height:150%">
<li style=3D"mso-line-height-rule:exactly">Rapid assessment of cell viabili=
ty in 3D cultures</li>
<li style=3D"mso-line-height-rule:exactly">Highly sensitive luminescent rea=
dout</li>
<li style=3D"mso-line-height-rule:exactly">Easy 3D cell culture and assay s=
etup in U-bottom microplates</li>
</ul></div></div></td></tr></tbody></table>
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