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✏️ Editing: 1693405976.M84961P3500526.aristoteles.x5servers.net,S=57596,W=59041:2,

Envelope-to: rcruz@sapasequipment.com
Delivery-date: Wed, 30 Aug 2023 10:32:56 -0400
Date: Wed, 30 Aug 2023 09:31:56 -0500 (CDT)
From: Sartorius <news@sartorius.com>
Reply-To: news@sartorius.com
To: rcruz@sapasequipment.com
Message-ID: <1246810314.3975884.1693405916750@nld1mktmail-batch1d.marketo.org>
Subject: Simplify the Characterization of ADCs
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From Molecule to Market: Simplifying the Characterization of ADCs
Antibody-drug conjugates (ADCs) are among the fastest growing class of biol=
ogics and are developed as a combination of monoclonal antibodies (mAbs) an=
d highly potent cytotoxic molecules (drugs). The antibody, in addition to i=
ts own biological specificity through its paratope, has the function of a t=
argeted transporting tool of the drug to the targeted cell. The conjugated =
molecules or particles typically have cytotoxic activity and thus increase =
the efficiency of the antibody by an additional mechanism, leading to incre=
ased death of cells carrying the target antigen.=20

Conjugation of these drugs to antibodies, however, increases structural com=
plexity which triggers the need for improved characterization methods utili=
zing technologies that can add biophysical and functional information.=20

This on-demand webinar <https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dR=
eSGmSmeUm7-lpFUO1Fo0b3q2anRsTCrr4zalCQQmV9VPdOzaH7SnTEq89xNwZdHoK8-c=3D> de=
monstrates the use of Octet=C2=AE=EF=B8=8F=20
Bio-Layer Interferometry (BLI) platform in combination with the iQue=C2=AE=
=EF=B8=8F Advanced Flow Cytometry Platform to characterize and compare the =
drug trastuzumab to the trastuzumab-containing reference medicinal products=
 (RMPs) Kadcyla=C2=AE=EF=B8=8F and Enhertu=C2=AE=EF=B8=8F.

Key Takeaways:
Assay considerations for ADCs characterization
Need for complimentary techniques for selection of optimal drug candidates

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ion: underline;"
> <img class=3D"mktoImg heroStageImageImg" id=3D"heroStageImageImgd55e4fe1-=
0274-4fb4-a64b-333c8e49237a" src=3D"https://info.sartorius.com/rs/609-TDQ-6=
77/images/Octet-mAB-BWbackground-WEB-812x456-en-L-Sartorius.png" style=3D"v=
ertical-align: middle; border: 0; outline: none; -ms-interpolation-mode: bi=
cubic; width: 640px;" width=3D"640" mktolockimgsize=3D"true" /> </a> </td>=
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</tr>=20
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<table class=3D"mktoModule spacer spacerOnWhite" id=3D"spacerOnWhitecf7c911=
c-fa21-442a-8af1-1ad6d9880dd3" style=3D"width: 100%; border: none; border-c=
ollapse: collapse; border-spacing: 0px; cellpadding: 0; cellspacing: 0; rol=
e: presentation; mso-table-lspace: 0pt; mso-table-rspace: 0pt; background-c=
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presentation" bgcolor=3D"#ffffff">=20
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eight: 20px; font-size: 0px; line-height: 0px;" height=3D"20" align=3D"left=
" valign=3D"top"> &nbsp; </td>=20
</tr>=20
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<table class=3D"mktoModule globalModule headline headlineOnWhite" id=3D"h1O=
nWhitef157da47-13d3-4dcf-87a0-e3a5be920885" style=3D"border: none; border-c=
ollapse: collapse; border-spacing: 0px; cellpadding: 0; cellspacing: 0; rol=
e: presentation; mso-table-lspace: 0pt; mso-table-rspace: 0pt; width: 100%;=
 background-color: #ffffff;" width=3D"100%" cellpadding=3D"0" cellspacing=
=3D"0" role=3D"presentation" bgcolor=3D"#ffffff">=20
<tbody>=20
<tr>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
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<td class=3D" mktoText globalModuleInner globalText globalH1 headlineText "=
 id=3D"h1OnWhiteText4fa3d5d8-bf75-4fe3-8307-b37e9258376f" style=3D"width: 5=
60px; font-family: Arial, sans-serif; font-weight: normal; text-align: left=
; color: #000000; vertical-align: top; font-size: 30px; line-height: 36px;"=
 width=3D"560" align=3D"left" valign=3D"top">From Molecule to Market: Simpl=
ifying the Characterization of ADCs</td>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
=3D"left" valign=3D"top">&nbsp;</td>=20
</tr>=20
<tr>=20
<td class=3D"headlineSpacerBottom" colspan=3D"3" height=3D"10px" style=3D"t=
ext-align: left; vertical-align: top; font-size: 0px; line-height: 0px; hei=
ght: 10px;" align=3D"left" valign=3D"top"> &nbsp; </td>=20
</tr>=20
</tbody>=20
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<table class=3D"mktoModule spacer spacerOnWhite" id=3D"spacerOnWhiteda3c2d9=
e-34b0-4563-9440-93cf809db49f" style=3D"width: 100%; border: none; border-c=
ollapse: collapse; border-spacing: 0px; cellpadding: 0; cellspacing: 0; rol=
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presentation" bgcolor=3D"#ffffff">=20
<tbody>=20
<tr>=20
<td class=3D"spacerInner" style=3D"text-align: left; vertical-align: top; h=
eight: 20px; font-size: 0px; line-height: 0px;" height=3D"20" align=3D"left=
" valign=3D"top"> &nbsp; </td>=20
</tr>=20
</tbody>=20
</table>
<table class=3D"mktoModule globalModule text textOnWhite" id=3D"textOnWhite=
56090705-7462-4109-96f0-6058282d55df" style=3D"border: none; border-collaps=
e: collapse; border-spacing: 0px; cellpadding: 0; cellspacing: 0; role: pre=
sentation; mso-table-lspace: 0pt; mso-table-rspace: 0pt; width: 100%; backg=
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<tbody>=20
<tr>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
=3D"left" valign=3D"top">&nbsp;</td>=20
<td class=3D"mktoText globalModuleInner globalText textText " id=3D"textOnW=
hiteText99b4528e-3875-4763-ae66-af7ee1c64d89" style=3D"width: 560px; font-f=
amily: Arial, sans-serif; font-weight: normal; font-size: 15px; line-height=
: 26px; text-align: left; color: #000000; vertical-align: top;" width=3D"56=
0" align=3D"left" valign=3D"top">Antibody-drug conjugates (ADCs) are among =
the fastest growing class of biologics and are developed as a combination o=
f monoclonal antibodies (mAbs) and highly potent cytotoxic molecules (drugs=
). The antibody, in addition to its own biological specificity through its =
paratope, has the function of a targeted transporting tool of the drug to t=
he targeted cell. The conjugated molecules or particles typically have cyto=
toxic activity and thus increase the efficiency of the antibody by an addit=
ional mechanism, leading to increased death of cells carrying the target an=
tigen. <br /><br />Conjugation of these drugs to antibodies, however, incre=
ases structural complexity which triggers the need for improved characteriz=
ation methods utilizing technologies that can add biophysical and functiona=
l information. <br /><br />This <a href=3D
"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSD78pEzgM4To6Hkp6jkNao=
DT7rislICqQWrCufafubbKPqLODI_XFIvFkiIeIU2k1WE=3D" target=3D"_blank" id=3D""
>on-demand webinar</a> demonstrates the use of Octet<sup>=C2=AE=EF=B8=8F</s=
up> Bio-Layer Interferometry (BLI) platform in combination with the iQue<su=
p>=C2=AE=EF=B8=8F</sup> Advanced Flow Cytometry Platform to characterize an=
d compare the drug trastuzumab to the trastuzumab-containing reference medi=
cinal products (RMPs) Kadcyla<sup>=C2=AE=EF=B8=8F</sup> and Enhertu<sup>=C2=
=AE=EF=B8=8F</sup>.<br /><br />Key Takeaways: </td>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
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</tr>=20
<tr>=20
<td class=3D"textSpacerBottom" colspan=3D"3" height=3D"10px" style=3D"text-=
align: left; vertical-align: top; font-size: 0px; line-height: 0px; height:=
 10px;" align=3D"left" valign=3D"top"> &nbsp; </td>=20
</tr>=20
</tbody>=20
</table>
<table class=3D"mktoModule globalModule bullet bulletOnWhite" id=3D"bulletS=
quareOnWhitee9353f66-0cc2-49e4-8a42-3cb486e8a422" style=3D"border: none; bo=
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0; role: presentation; mso-table-lspace: 0pt; mso-table-rspace: 0pt; width:=
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<tbody>=20
<tr>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
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<td class=3D"globalModuleInner" style=3D"width: 560px; text-align: center; =
vertical-align: top;" width=3D"560" align=3D"center" valign=3D"top">=20
<table style=3D"width: 100%; border: none; border-collapse: collapse; borde=
r-spacing: 0px; cellpadding: 0; cellspacing: 0; role: presentation; mso-tab=
le-lspace: 0pt; mso-table-rspace: 0pt;" width=3D"100%" cellpadding=3D"0" ce=
llspacing=3D"0" role=3D"presentation">=20
<tbody>=20
<tr>=20
<td class=3D" globalText bulletSquareColLeft " style=3D"font-family: Arial,=
 sans-serif; font-weight: normal; text-align: left; color: #000000; vertica=
l-align: top; width: 25px; font-size: 12px; line-height: 22px;" width=3D"25=
" align=3D"left" valign=3D"top"> =E2=96=A0 </td>=20
<td class=3D"mktoText globalText bulletSquareColRight" id=3D"bulletSquareOn=
WhiteText1f855278-00ab-48ce-bc81-45590e9fc966" style=3D"font-family: Arial,=
 sans-serif; font-weight: normal; font-size: 15px; line-height: 26px; text-=
align: left; color: #000000; vertical-align: top; width: 535px;" width=3D"5=
35" align=3D"left" valign=3D"top">Assay considerations for ADCs characteriz=
ation</td>=20
</tr>=20
</tbody>=20
</table> </td>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
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</tr>=20
<tr>=20
<td class=3D"bulletSpacerBottom" colspan=3D"3" height=3D"10px" style=3D"tex=
t-align: left; vertical-align: top; font-size: 0px; line-height: 0px; heigh=
t: 10px;" align=3D"left" valign=3D"top"> &nbsp; </td>=20
</tr>=20
</tbody>=20
</table>
<table class=3D"mktoModule globalModule bullet bulletOnWhite" id=3D"bulletS=
quareOnWhite4adbf510-30cf-47c1-a8c0-93131665bb55" style=3D"border: none; bo=
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0; role: presentation; mso-table-lspace: 0pt; mso-table-rspace: 0pt; width:=
 100%; background-color: #ffffff;" width=3D"100%" cellpadding=3D"0" cellspa=
cing=3D"0" role=3D"presentation" bgcolor=3D"#ffffff">=20
<tbody>=20
<tr>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
=3D"left" valign=3D"top">&nbsp;</td>=20
<td class=3D"globalModuleInner" style=3D"width: 560px; text-align: center; =
vertical-align: top;" width=3D"560" align=3D"center" valign=3D"top">=20
<table style=3D"width: 100%; border: none; border-collapse: collapse; borde=
r-spacing: 0px; cellpadding: 0; cellspacing: 0; role: presentation; mso-tab=
le-lspace: 0pt; mso-table-rspace: 0pt;" width=3D"100%" cellpadding=3D"0" ce=
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<tbody>=20
<tr>=20
<td class=3D" globalText bulletSquareColLeft " style=3D"font-family: Arial,=
 sans-serif; font-weight: normal; text-align: left; color: #000000; vertica=
l-align: top; width: 25px; font-size: 12px; line-height: 22px;" width=3D"25=
" align=3D"left" valign=3D"top"> =E2=96=A0 </td>=20
<td class=3D"mktoText globalText bulletSquareColRight" id=3D"bulletSquareOn=
WhiteText957f5558-efd0-4663-8143-087b4f605531" style=3D"font-family: Arial,=
 sans-serif; font-weight: normal; font-size: 15px; line-height: 26px; text-=
align: left; color: #000000; vertical-align: top; width: 535px;" width=3D"5=
35" align=3D"left" valign=3D"top">Need for complimentary techniques for sel=
ection of optimal drug candidates</td>=20
</tr>=20
</tbody>=20
</table> </td>=20
<td class=3D"globalModuleSpacerHor" style=3D"text-align: left; vertical-ali=
gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
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</tr>=20
<tr>=20
<td class=3D"bulletSpacerBottom" colspan=3D"3" height=3D"10px" style=3D"tex=
t-align: left; vertical-align: top; font-size: 0px; line-height: 0px; heigh=
t: 10px;" align=3D"left" valign=3D"top"> &nbsp; </td>=20
</tr>=20
</tbody>=20
</table>
<table class=3D"mktoModule spacer spacerOnWhite" id=3D"spacerOnWhitea9cba2b=
d-e99c-4bf0-b722-d283b44fd2ff" style=3D"width: 100%; border: none; border-c=
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presentation" bgcolor=3D"#ffffff">=20
<tbody>=20
<tr>=20
<td class=3D"spacerInner" style=3D"text-align: left; vertical-align: top; h=
eight: 20px; font-size: 0px; line-height: 0px;" height=3D"20" align=3D"left=
" valign=3D"top"> &nbsp; </td>=20
</tr>=20
</tbody>=20
</table>
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ormalOnWhite2bce6b0a-8c2f-4ed4-bbab-2737caa43532" style=3D"border: none; bo=
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0; role: presentation; mso-table-lspace: 0pt; mso-table-rspace: 0pt; width:=
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<tbody>=20
<tr>=20
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<td class=3D"globalModuleInner" style=3D"width: 560px; text-align: center; =
vertical-align: top;" width=3D"560" align=3D"center" valign=3D"top">=20
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padding=3D"0" cellspacing=3D"0" role=3D"presentation">=20
<tbody>=20
<tr>=20
<td style=3D"text-align: left; vertical-align: top;" align=3D"left" valign=
=3D"top">=20
<table class=3D" btnWrapper " style=3D"border: none; border-collapse: colla=
pse; border-spacing: 0px; cellpadding: 0; cellspacing: 0; role: presentatio=
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<tbody>=20
<tr>=20
<td class=3D" btnInner btnInnerColorPrimary " style=3D"text-align: left; ba=
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f=3D
"https://click.sartorius.com/dc/5HL5y5hF-ppxojJP01Mr_NE3DcKpl2t_T_Wx4azHd4u=
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 normal; line-height: 24px; mso-line-height-rule: exactly; text-decoration:=
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> Watch Now </a> </td>=20
</tr>=20
</tbody>=20
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</tr>=20
</tbody>=20
</table> </td>=20
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p;" align=3D"left" valign=3D"top"><a class=3D"btnOutlineLink btnOutlineLink=
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font-family: Arial,                                                        =
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align: top; height: 20px; font-size: 0px; line-height: 0px;" height=3D"20" =
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align: top; font-weight: normal; width: 20px; font-size: 0px; line-height: =
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t" valign=3D"middle">=20
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<td class=3D"footerSocialListItem" style=3D"text-align: left; vertical-alig=
n: top; width: 40px;" width=3D"40" align=3D"left" valign=3D"top"><a class=
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3nsWf91-qPQrwddVg8Xeols5wUvXytZyVmQNIA-y_QSkU=3D" target=3D"_blank" style=
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> <img class=3D"footerSocialListImg" src=3D"https://info.sartorius.com/rs/6=
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gn: middle; border: 0; outline: none; -ms-interpolation-mode: bicubic; widt=
h: 40px;" width=3D"40" /> </a></td>=20
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ical-align: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"4=
0" align=3D"left" valign=3D"top">&nbsp;</td>=20
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n: top; width: 40px;" width=3D"40" align=3D"left" valign=3D"top"><a class=
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> <img class=3D"footerSocialListImg" src=3D"https://info.sartorius.com/rs/6=
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ical-align: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"4=
0" align=3D"left" valign=3D"top">&nbsp;</td>=20
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n: top; width: 40px;" width=3D"40" align=3D"left" valign=3D"top"><a class=
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"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSFThAaAzVRs0KdKj_ox3Lu=
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> <img class=3D"footerSocialListImg" src=3D"https://info.sartorius.com/rs/6=
09-TDQ-677/images/youtube-icon.png" alt=3D"YouTube" style=3D"vertical-align=
: middle; border: 0; outline: none; -ms-interpolation-mode: bicubic; width:=
 40px;" width=3D"40" /> </a></td>=20
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ical-align: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"4=
0" align=3D"left" valign=3D"top">&nbsp;</td>=20
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n: top; width: 40px;" width=3D"40" align=3D"left" valign=3D"top"><a class=
=3D"footerSocialListLink" href=3D
"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSE7b5LWyaT3sUIU6tA_E2e=
fth9KxnXdQmP9_9G9TlYlJsUt8yLQIk8I0iP3MOuizy4I=3D" target=3D"_blank" style=
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> <img class=3D"footerSocialListImg" src=3D"https://info.sartorius.com/rs/6=
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gn: middle; border: 0; outline: none; -ms-interpolation-mode: bicubic; widt=
h: 40px;" width=3D"40" /> </a></td>=20
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eft; vertical-align: top; height: 20px; font-size: 0px; line-height: 0px;" =
height=3D"20" align=3D"left" valign=3D"top">&nbsp;</td>=20
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<td style=3D"text-align: left; vertical-align: top;" align=3D"left" valign=
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<table class=3D"footerLegal" style=3D"border: none; border-collapse: collap=
se; border-spacing: 0px; cellpadding: 0; cellspacing: 0; role: presentation=
; mso-table-lspace: 0pt; mso-table-rspace: 0pt; width: 515px;" width=3D"515=
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<td class=3D"globalText footerLegalCol" style=3D"font-family: Arial, sans-s=
erif; font-weight: normal; text-align: left; vertical-align: top; width: 22=
5px; font-size: 12px; line-height: 16px; color: #ffffff;" width=3D"225" ali=
gn=3D"left" valign=3D"top">Published by<br /> Sartorius AG<br /> Otto-Brenn=
er-Stra=C3=9Fe 20<br /> 37079 Goettingen, Germany<br /><br /> Phone +49.551=
.308-0<br /> Fax +49.551.308-3289<br /> <a class=3D"globalLink footerLink" =
href=3D
"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSJVXdoB4H4zkrH9UzwwMQV=
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>newsletter@sartorius.com<br /> </a><a class=3D"globalLink footerLink" href=
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"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSMtwKOg8vVOlPHOty0G4Ia=
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>www.sartorius.com</a><br /><br /> Executive Board Chairman<br /> Dr. Joach=
im Kreuzburg, Dr. Ren=C3=A9 F=C3=A1ber,<br /> Dr. Alexandra Gatzemeyer,<br =
/> Rainer Lehmann</td>=20
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erif; font-weight: normal; text-align: left; vertical-align: top; width: 22=
5px; font-size: 12px; line-height: 16px; color: #ffffff;" width=3D"225" ali=
gn=3D"left" valign=3D"top">Chairman of the Supervisory Board:<br /> Dr. Lot=
har Kappich<br /> Registered Office:<br /> Goettingen, Germany<br /><br /> =
Local Court of Registration:<br /> Amtsgericht Goettingen, HRB No. 1970<br =
/> Vat No. DE 115 302 222<br /><br /> <strong>Unsubscribe newsletter or upd=
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lobalLink footerLink" href=3D
"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSCro_L7dezkVg4R0Td2iZM=
wXsDmcqQhACHVjj7WF6s9WRcjUmg8huXqadPiXcCRai8Y=3D" style=3D"text-decoration:=
 underline; font-weight: normal; color: #ffffff;"
>click here. </a></strong><br /><br /><strong>Further information on the pr=
ocessing of personal data can be found in the <a class=3D"globalLink footer=
Link" href=3D
"https://click.sartorius.com/NjA5LVREUS02NzcAAAGN5dReSIB2RYJE3opBnPVCBpg7EB=
FqqoCKqJKV6o9MVbCZgt3PfWV3rBhIk7Tkp92qwwwJHvI=3D" style=3D"text-decoration:=
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>Sartorius Data Privacy Notice.</a></strong></td>=20
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gn: top; width: 40px; font-size: 0px; line-height: 0px;" width=3D"40" align=
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ft; vertical-align: top; font-size: 0px; line-height: 0px; height: 30px;" h=
eight=3D"30" align=3D"left" valign=3D"top">&nbsp;</td>=20
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