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Envelope-to: rcruz@sapasequipment.com
Delivery-date: Wed, 03 Jan 2024 10:01:50 -0400
Date: Wed, 3 Jan 2024 08:01:04 -0600 (CST)
From: 
	The Sievers Instruments Team <from@solutions.watertechnologies.veolia.com>
Reply-To: SieversInstruments@veolia.com
To: rcruz@sapasequipment.com
Message-ID: <1012302552.131620184.1704290464716@sjmktmail-batch1d.marketo.org>
Subject: 5 Tips for Balancing Sustainability with Compliance
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Hello Richard,

Sustainability and compliance shouldn=E2=80=99t be an either/or situation w=
hen it comes to pharmaceutical manufacturing and analytical testing.

Common sustainability initiatives include reducing consumption of limited r=
esources, understanding the impact of operations on the environment and peo=
ple, and developing strategies to become more sustainable in the future. Th=
ese initiatives must be balanced with the strict regulatory requirements th=
at are in place to ensure the manufacturing of safe drug products.

Here are five tips from Sievers Instruments on balancing sustainability and=
 compliance:

=09- Lean principles and sustainability- Implement lean technologies=C2=A0t=
o increase efficiency, eliminate quality deviations, and/or more rapidly id=
entify out-of-specification (OOS) trends.
=09- Water use & quality- Ensure your water for pharmaceutical use meets th=
e regulatory requirements for purity. Take advantage of instrumentation for=
 total organic carbon (TOC), conductivity, endotoxins, and bioburden that m=
ake compliance, process control, and management of resources easier.
=09- Endotoxin testing <https://em.watertechnologies.com/NzQyLU1KRC03MDkAAA=
GQbpljyMCIiQAECT07QesEyW-WAoSQj-AOQgsH8cTCwcIkp5TczgmSCbVzjxSnorowVyPcWhs=
=3D>- Deploy technology like centripetal microfluidics that cuts back on th=
e use of LAL (derived from natural resources) by 90%. Non only can you decr=
ease assay setup time by 85%, reduce demand on natural resources, and reduc=
e pipetting steps from 200+ to less than 30, but you can minimize the use o=
f pipette tips and reagent storage thus improving efficiency while reducing=
 the lab=E2=80=99s footprint.
=09- Real-time release testing <https://em.watertechnologies.com/NzQyLU1KRC=
03MDkAAAGQbpljyCMilV7I4DRYlMKmEK26254Epto6m4lBJ9BbkwgzOH1qzaPcpXzQWNi9xxZmL=
u8wRKA=3D>- Transition from lab, to at-line, to online water testing to lea=
n out the labor and consumables required while increasing efficiency.
=09- Rapid microbiological methods (RMMs) <https://em.watertechnologies.com=
/NzQyLU1KRC03MDkAAAGQbpljyJt5kAUMLJ6WZ2OjXmxyAD-icnfPQqFS_pEWItn_7xiU6BEqNl=
afxEMpyMcGBzwbWnc=3D>- Mitigate risk and reduce the time and resources requ=
ired for traditional bioburden testing by implementing an RMM. These method=
s finally let manufacturers know when they have a contamination event in ne=
ar real-time, lending to faster decisions impacting potential product loss =
and management of resources.
Sincerely,=20

The Sievers Instruments Team
 VEOLIA WATER TECHNOLOGIES & SOLUTIONS,
 Analytical Instruments
 E: SieversInstruments@veolia.com <https://em.watertechnologies.com/NzQyLU1=
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<tr>=20
<td width=3D"5%" style=3D"vertical-align:top;min-width:5%"></td>=20
<td width=3D"90%" valign=3D"top">=20
<table class=3D"full-width" cellpadding=3D"0" cellspacing=3D"0" border=3D"0=
" width=3D"100%" style=3D"margin:0 auto; table-layout:fixed" align=3D"left"=
>=20
<tbody>=20
<tr>=20
<td style=3D"-moz-osx-font-smoothing:grayscale; -webkit-font-smoothing:anti=
aliased; font-family:Arial, Verdana, sans-serif; font-size:16px; font-weigh=
t:400; letter-spacing:0px; line-height:24px; margin-top:0px; margin-bottom:=
0px; padding:0; word-wrap:normal;  text-align:left; color:#2C2C2C"> <p styl=
e=3D"-moz-osx-font-smoothing:grayscale; -webkit-font-smoothing:antialiased;=
 font-family:Arial, Verdana, sans-serif; font-size:16px; font-weight:400; l=
etter-spacing:0px; line-height:24px; margin-top:0px; margin-bottom:0px; pad=
ding:0; word-wrap:normal;  text-align:left; color:#2C2C2C"> <span class=3D"=
mktoText" id=3D"full-width-reading-textc4c0fe76-dbf9-45f0-8542-8f7e1fa1c533=
"></span></p><p>Hello Richard,</p> <p>Sustainability and compliance shouldn=
=E2=80=99t be an either/or situation when it comes to pharmaceutical manufa=
cturing and analytical testing.</p> <p>Common sustainability initiatives in=
clude reducing consumption of limited resources, understanding the impact o=
f operations on the environment and people, and developing strategies to be=
come more sustainable in the future. These initiatives must be balanced wit=
h the strict regulatory requirements that are in place to ensure the manufa=
cturing of safe drug products.</p> <p>Here are five tips from Sievers Instr=
uments on balancing sustainability and compliance:</p>=20
<ol>=20
<li>Lean principles and sustainability- Implement lean technologies&nbsp;to=
 increase efficiency, eliminate quality deviations, and/or more rapidly ide=
ntify out-of-specification (OOS) trends.</li>=20
<li>Water use &amp; quality- Ensure your water for pharmaceutical use meets=
 the regulatory requirements for purity. Take advantage of instrumentation =
for total organic carbon (TOC), conductivity, endotoxins, and bioburden tha=
t make compliance, process control, and management of resources easier.</li=
>=20
<li><span style=3D"text-decoration: underline;"><a href=3D
"https://em.watertechnologies.com/NzQyLU1KRC03MDkAAAGQbpljyMCIiQAECT07QesEy=
W-WAoSQj-AOQgsH8cTCwcIkp5TczgmSCbVzjxSnorowVyPcWhs=3D" target=3D"_blank"
>Endotoxin testing</a></span>- Deploy technology like centripetal microflui=
dics that cuts back on the use of LAL (derived from natural resources) by 9=
0%. Non only can you decrease assay setup time by 85%, reduce demand on nat=
ural resources, and reduce pipetting steps from 200+ to less than 30, but y=
ou can minimize the use of pipette tips and reagent storage thus improving =
efficiency while reducing the lab=E2=80=99s footprint.</li>=20
<li><span style=3D"text-decoration: underline;"><a href=3D
"https://em.watertechnologies.com/NzQyLU1KRC03MDkAAAGQbpljyCMilV7I4DRYlMKmE=
K26254Epto6m4lBJ9BbkwgzOH1qzaPcpXzQWNi9xxZmLu8wRKA=3D" target=3D"_blank" id=
=3D""
>Real-time release testing</a></span>- Transition from lab, to at-line, to =
online water testing to lean out the labor and consumables required while i=
ncreasing efficiency.</li>=20
<li><span style=3D"text-decoration: underline;"><a href=3D
"https://em.watertechnologies.com/NzQyLU1KRC03MDkAAAGQbpljyJt5kAUMLJ6WZ2OjX=
mxyAD-icnfPQqFS_pEWItn_7xiU6BEqNlafxEMpyMcGBzwbWnc=3D" target=3D"_blank" id=
=3D""
>Rapid microbiological methods (RMMs)</a></span>- Mitigate risk and reduce =
the time and resources required for traditional bioburden testing by implem=
enting an RMM. These methods finally let manufacturers know when they have =
a contamination event in near real-time, lending to faster decisions impact=
ing potential product loss and management of resources.</li>=20
</ol> <p></p> </td>=20
</tr>=20
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ing=3D"0" bgcolor=3D"#FFFFFF" style=3D"width:640px; margin:0 auto; table-la=
yout:fixed; min-width:640px;">=20
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<center>=20
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<td width=3D"100%" style=3D"text-align:center; background-color:none; font-=
family:Arial, Verdana, sans-serif;"> <a href=3D
"https://em.watertechnologies.com/NzQyLU1KRC03MDkAAAGQbpljyOmYgRNySnLCZ7e4B=
QtuNG7QGhW6p0AWRIwJgOgXljU8UPYSnXdEF93X3KZLo-u_bGc=3D" style=3D"text-decora=
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k; width:100%;"
>=20
<div style=3D"background-color:#FFD616; padding:12px 24px; border-radius: 0=
px; border-width:2px; border-style:solid; border-color:#FFD616">=20
<span> Explore more </span>=20
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ut:fixed; min-width:640px;">=20
<tbody>=20
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<td style=3D"font-size:2px; line-height:30px">&nbsp;</td>=20
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<table id=3D"mktoModule065bd7aa71-54d4-416d-b956-9abb3fdbde15" class=3D"ful=
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<table class=3D"full-width" cellpadding=3D"0" cellspacing=3D"0" border=3D"0=
" width=3D"100%" style=3D"margin:0 auto; table-layout:fixed" align=3D"left"=
>=20
<tbody>=20
<tr>=20
<td style=3D"-moz-osx-font-smoothing:grayscale; -webkit-font-smoothing:anti=
aliased; font-family:Arial, Verdana, sans-serif; font-size:16px; font-weigh=
t:400; letter-spacing:0px; line-height:24px; margin-top:0px; margin-bottom:=
0px; padding:0; word-wrap:normal;  text-align:left; color:#2C2C2C"> <p styl=
e=3D"-moz-osx-font-smoothing:grayscale; -webkit-font-smoothing:antialiased;=
 font-family:Arial, Verdana, sans-serif; font-size:16px; font-weight:400; l=
etter-spacing:0px; line-height:24px; margin-top:0px; margin-bottom:0px; pad=
ding:0; word-wrap:normal;  text-align:left; color:#2C2C2C"> <span class=3D"=
mktoText" id=3D"full-width-reading-text3c319b3f-2bef-44ff-8593-a81b0c1158b8=
"></span></p><p><span style=3D"line-height: 105%; font-family: arial, helve=
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