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Subject: Download: Unlocking Chromatographic Analysis of Peptides in the GI
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Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VVFG1H7lMZwHVvFSBp=
5KLn_9W6P_DFt5bQGG5N8tN9Dx3prCCW95jsWP6lZ3pWW7R4N821dQNxKW6jWg_B1mpzB6N5p2N=
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SyNW2dxDZg1TFR3BW2Z5VzB4p_pq3N2hZXYLlH7ZWW6VP-6_4FfLShf3k4Htv04 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/VVFG1H7lMZwHVvFSBp5KLn_9W6P_DFt5bQGG5N8tN9Dx3prCCW95jsWP6lZ3pWW7R4N821d=
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hf3k4Htv04 ) examines use of the polymer-based reversed-phase resin (PRP-3)=
 for the successful chromatographic separation of seven key GPCR binding pe=
ptides. The conditions and performance characteristics are described as wel=
l as the putative mechanism underlying isolation.

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hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"color: inherit; =
font-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widg=
et" data-hs-cos-type=3D"module"><table class=3D"hse-image-wrapper" role=3D"=
presentation" width=3D"100%" cellpadding=3D"0" cellspacing=3D"0" style=3D"b=
order-spacing:0 !important; border-collapse:collapse; mso-table-lspace:0pt;=
 mso-table-rspace:0pt">
  <tbody>
    <tr>
      <td align=3D"center" valign=3D"top" style=3D"border-collapse:collapse=
; mso-line-height-rule:exactly; font-family:Georgia, serif; color:#23286b; =
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rXW8xVTYY52h28pW6-H-M6130023Ml_kZT5HJdTW5WkM7y4LYBy0VZCYBH56SLxXW8DCKZD3vqR=
6qW8-nGTn442bp-Vc-4J38kWpZ-W15B3Gm2fYy7xW4T1smH3jq8p_W3whwQy56d_W6VQ1Qcr89R=
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      <div class=3D"hse-column-container" style=3D"min-width:280px; max-wid=
th:600px; Margin-left:auto; Margin-right:auto; border-collapse:collapse; bo=
rder-spacing:0; background-color:#FFFFFF; padding-bottom:10px; padding-top:=
8px" bgcolor=3D"#FFFFFF">
    
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<div id=3D"column-2-0" class=3D"hse-column hse-size-12">
  <table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D=
"100%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-=
table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
style=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-famil=
y:Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; pad=
ding:10px 20px"><div id=3D"hs_cos_wrapper_module_16239611830074" class=3D"h=
s_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"co=
lor: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-genera=
l-type=3D"widget" data-hs-cos-type=3D"module">
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role=3D"presentation" style=3D"border-spacing:0 !important; mso-table-lspac=
e:0pt; mso-table-rspace:0pt; border-collapse:separate!important">
    <tbody><tr>
        
    
      <td align=3D"center" valign=3D"middle" bgcolor=3D"#D2232B" style=3D"b=
order-collapse:collapse; mso-line-height-rule:exactly; font-family:Georgia,=
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        <a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/=
VVFG1H7lMZwHVvFSBp5KLn_9W6P_DFt5bQGG5N8tN9Dx3qgyTW95jsWP6lZ3m-V7lGN94QD-KSW=
6ZlY2R5bXWR8W2VnNsJ5vZK_dW4F1QYY50DbcrW5-sg0-7JH9PgW2XsXyj1xWGWbW2Bp_K452Dr=
rlW162Bnm6C71_NW3xlfzv7jzWJGW87XRLG4Tv6RRW8VdlRL771qSYW5Lx6x-42-XfxW1DY1gy7=
lgV8vW5D_2LW7yjP1tW2fpcmc92NN55N6FjFl-vs8N-W2bWZ5H24lhDJW6_s5W-7RrWv-V5H-7s=
69_f93W5dk_tq3DFtyhN3LCTYhj4FhvVz6YnX3pWrRpVyWMHn6hh4xLW1CjjRd2lt1Q5MLw47-J=
HtSPW7fw-4b7wNrF0W8x5fps5WDwpnW95j82w43NvW6W2RPrdb2wVrv1W1J3Gyy3VZf3tf4J03K=
004" target=3D"_blank" style=3D"color:#00a4bd; mso-line-height-rule:exactly=
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d=3D"2">
          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
:none;font-style:normal;">Download Application Note</strong>
        </a>
      </td>
    </tr>
  </tbody></table>
</div></td></tr></tbody></table>
<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VV=
FG1H7lMZwHVvFSBp5KLn_9W6P_DFt5bQGG5N8tN9Dx3qgyTW95jsWP6lZ3nRW18g3j57NQqVFW7=
wXykv6ljPYdW10s8lz469zdbW6vywSv4YvDF2W6Q756b7QmpjWW7zTV1_5wlmj7VRhTQ52fjXsY=
N2j2CBjJDgvnW8Fd54K4cwCs2W65-fVr44h3gzW3MqGKv1-bHMYW7Vw7ng4QRFTKW6Hxpn63D42=
3yW12Sl3F8GB_p6VjCbZg2y2FXGW67fjtT2jRt2JW5mbNzR5B9c0YW42vcjK2R1ZzGW2jnmd53f=
6DvdW7d2rVt4cwDpLN1gCVQpmJzwSW8HtmWz49lQx6VP0JmM7bZbVfW3lsYW_5W94jLW5bFw9L1=
Sp48pW8x706P1cGyW1W5rt0D-7F90KcW2JqdSc6_0vWYW68yPtB7HtXMhW3HY03D5Ycwz-f892k=
Yj04" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929eb2=
" data-hs-link-id=3D"3" target=3D"_blank">This application note</a> examine=
s use of the polymer-based reversed-phase resin (PRP-3) for the successful =
chromatographic separation of seven key GPCR binding peptides. The conditio=
ns and performance characteristics are described as well as the putative me=
chanism underlying isolation. </span></span></p></div></div></td></tr></tbo=
dy></table>
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