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Delivery-date: Sat, 23 Mar 2024 10:05:07 -0400
Date: Sat, 23 Mar 2024 10:04:25 -0400
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Subject: New Platform for icIEF Fractionation of Antibody Charge Variants
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MauriceFlex: A Novel Platform for icIEF Fractionation of Antibody Charge Va=
riants

The MauriceFlex=E2=84=A2 system is an innovative automated capillary electr=
ophoresis platform featuring icIEF-based fractionation. This platform is id=
eal for collecting protein charge variants and enabling downstream analysis=
 using mass spectrometry and other analytical techniques.

Compared to ion-exchange chromatography (IEX) based fractionation, MauriceF=
lex fractionation is fast, provides high pI-based resolution, and overcomes=
 key limitations of previous techniques, such as the need for special mass =
spec equipment and incompatibility with the background electrolytes.

This application note takes a deep dive into the advantages of this novel p=
latform for mAb peptide mapping and other challenging applications.

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<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">MauriceFlex: A Novel Platform for icIEF Fractionation of Antibod=
y Charge Variants</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The MauriceFlex=E2=84=A2 system is an innovative automated capillary =
electrophoresis platform featuring icIEF-based fractionation. This platform=
 is ideal for collecting protein charge variants and enabling downstream an=
alysis using mass spectrometry and other analytical techniques.</span></spa=
n></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Compared to ion-exchange chromatography (IEX) based fractionation, Ma=
uriceFlex fractionation is fast, provides high pI-based resolution, and ove=
rcomes key limitations of previous techniques, such as the need for special=
 mass spec equipment and incompatibility with the background electrolytes.<=
/span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">This application note takes a deep dive into the advantages of this n=
ovel platform for mAb peptide mapping and other challenging applications.</=
span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p></div></div></td></tr></tbody></table>
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