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Subject: Download: Exploring Chromatographic Isolation of Key GPCR Binding
 Peptides
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Hn004 )

Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/MW_Lt_94VPwW2mFBZq=
4Q4CdrW11fj5c5chncsN6hnpqq3prCCW95jsWP6lZ3psW7-jMzq908DvTW6Srln-15wH49W8Flz=
L28xRC66W32K7J34_kkcWVFQq6Y4t95lKW6Zl1M07SVXnWW3p-ry24LK56xW5WyRq63tks7mN3d=
MG01ykDTQW589zQB34pxmwW2HdScK63W8DjW56xWwM5DRwVjW99_BJn9fkzRgN33pg61fBxHjW7=
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W4wR73M5kJyryW215NBy633KNBVJHQLK52VCcVW8ZhWf04wW5nfW1k-5W07nLWCZW7w1ZRZ2yFB=
m_W4N4G7G1k4pr3W3YZ4fG7kx34bW4P9nWM2MHpQ-W6BT1d_7Ylqp7dtrHn004 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/MW_Lt_94VPwW2mFBZq4Q4CdrW11fj5c5chncsN6hnpqq3prCCW95jsWP6lZ3psW7-jMzq90=
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Jn9fkzRgN33pg61fBxHjW7ffWzZ5P1FLGW4lDbpH6p48HqW250x9x3v_7xDW5Ghp1p4QCZMkW3H=
sf1p4MQhj4VGHtxz1fQcy2W4wR73M5kJyryW215NBy633KNBVJHQLK52VCcVW8ZhWf04wW5nfW1=
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7dtrHn004 ) examines use of the polymer-based reversed-phase resin (PRP-3) =
for the successful chromatographic separation of seven key GPCR binding pep=
tides. The conditions and performance characteristics are described as well=
 as the putative mechanism underlying isolation.

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hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"color: inherit; =
font-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widg=
et" data-hs-cos-type=3D"module"><table class=3D"hse-image-wrapper" role=3D"=
presentation" width=3D"100%" cellpadding=3D"0" cellspacing=3D"0" style=3D"b=
order-spacing:0 !important; border-collapse:collapse; mso-table-lspace:0pt;=
 mso-table-rspace:0pt">
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      <td align=3D"center" valign=3D"top" style=3D"border-collapse:collapse=
; mso-line-height-rule:exactly; font-family:Georgia, serif; color:#23286b; =
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t_W77QHnP3QVKQ-W1lgjl-7bXBx5W7q-RRc4LnwVNW4g6yDj4fPbB-W38T_Tt6hLr88W4SXzkj2=
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th:600px; Margin-left:auto; Margin-right:auto; border-collapse:collapse; bo=
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8px" bgcolor=3D"#FFFFFF">
    
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<div id=3D"column-2-0" class=3D"hse-column hse-size-12">
  <table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D=
"100%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-=
table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
style=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-famil=
y:Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; pad=
ding:10px 20px"><div id=3D"hs_cos_wrapper_module_16239611830074" class=3D"h=
s_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"co=
lor: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-genera=
l-type=3D"widget" data-hs-cos-type=3D"module"><table align=3D"center" borde=
r=3D"0" cellpadding=3D"0" cellspacing=3D"0" role=3D"presentation" style=3D"=
border-spacing:0 !important; mso-table-lspace:0pt; mso-table-rspace:0pt; bo=
rder-collapse:separate!important">
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      <td align=3D"center" valign=3D"middle" bgcolor=3D"#D2232B" style=3D"b=
order-collapse:collapse; mso-line-height-rule:exactly; font-family:Georgia,=
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:20px; cursor:auto; background-color:#D2232B">
   
        <a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/=
MW_Lt_94VPwW2mFBZq4Q4CdrW11fj5c5chncsN6hnpqq3qgyTW95jsWP6lZ3nzVz21Mh5rFL2FW=
4s2hLJ870wxfW2nx9Gh8s01sxW4dvtVQ8vwTxgW38L92_5SltYVW150Fb_8xPcfxW7j_gRG3Jvz=
23W6HqsGD2RMdG1W7W-Xf47-vdm2W1HM9x91Kxzm1W9kSBBw2klw_VW87cp0F3Rvy-dW7RXtHk6=
NbjdZW1KbXSP3QLPwbN2gKJ1zn3tbTW8Btgbn17GS3XMhltG8mswM3W3Zqz6Y3Wg2TjW2zbpkb2=
WG1MWW5b9nkk7h9187W86TRkS1pmg9tW6hQ3z328_jV-W3lcPMQ5g52DQVDKGfL5YKmJtVV70Qn=
8BW4xbW7gGGFn5Lm5fdW3KHJ5R1pVlJfW6FrR984Xrg1FN6SGGDbHG2n_W7hkdLQ9f-_1Yf83Lr=
Qv04" target=3D"_blank" style=3D"color:#00a4bd; mso-line-height-rule:exactl=
y; font-size:22px; font-family:Arial, sans-serif; Margin:0; text-transform:=
none; text-decoration:none; padding:12px 18px; display:block" data-hs-link-=
id=3D"2">
          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
:none;font-style:normal;">Download Application Note</strong>
        </a>
      </td>
    </tr>
  </tbody></table></div></td></tr></tbody></table>
<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/MW=
_Lt_94VPwW2mFBZq4Q4CdrW11fj5c5chncsN6hnpqq3qgyTW95jsWP6lZ3mRW8j7NrD8rnzH-W5=
mgwV49jTDXvW1wJq511fMS8MW61Xf_p97rBZbW99zLkz7d2CY7W3scXj42dTT_4W4CZYHV5yTZN=
YW1WPSlN6qhc7TW1KV2Nk2HX1ccW82V18-8l4YJGW19tvlV7P35jtVJkxgg1frrRpW2bcXMm207=
ZC0W7yTCjH5pL7yCV1RdyT73fx4xW5dRZH61_6L-TW1dds236Zdg4NVctRvc3zR7pWW8mq2SB3-=
J2HRN50Y-g2L09gLW7C8bgM85YsCrW2t3wnv5HhPgwVG8s8Z8dByDhW5T3qM_4xt2wNW7c2tsf4=
6lcNhV-fTy27VWXt9W83lkw53yQ7Y3W7kpkt68CZ1CXVCnbdf66VcFXW9k5kdb8GBRSGf3P_mwP=
04" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929eb2" =
data-hs-link-id=3D"3" target=3D"_blank">This application note</a> examines =
use of the polymer-based reversed-phase resin (PRP-3) for the successful ch=
romatographic separation of seven key GPCR binding peptides. The conditions=
 and performance characteristics are described as well as the putative mech=
anism underlying isolation. </span></span></p></div></div></td></tr></tbody=
></table>
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