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Subject: Download: Unlocking Chromatographic Analysis of Peptides in the GI
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Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VW8N7V58kvW2W1__lN=
v9fwwkzVNrtzX5cHRWZN5g75kd3prCCW95jsWP6lZ3pjW1qvvG_1dWH5JW81v20v7XhlGFN7YLj=
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gW58mqqS3xzRydW1s0y9R6Ywjh0W96vHhD5J5tbFW47ZddV15NF_tW1RZhPV6jxcFbW45vCVC8_=
7D2sW7V0Gf-1yqx17W80bynz8G61zPN5bmzXcgnJ8DVxdLmN91R5s6f5vwt5K04 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/VW8N7V58kvW2W1__lNv9fwwkzVNrtzX5cHRWZN5g75kd3prCCW95jsWP6lZ3pjW1qvvG_1d=
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6f5vwt5K04 ) examines use of the polymer-based reversed-phase resin (PRP-3)=
 for the successful chromatographic separation of seven key GPCR binding pe=
ptides. The conditions and performance characteristics are described as wel=
l as the putative mechanism underlying isolation.

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font-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widg=
et" data-hs-cos-type=3D"module"><table class=3D"hse-image-wrapper" role=3D"=
presentation" width=3D"100%" cellpadding=3D"0" cellspacing=3D"0" style=3D"b=
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      <td align=3D"center" valign=3D"top" style=3D"border-collapse:collapse=
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table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
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        <a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/=
VW8N7V58kvW2W1__lNv9fwwkzVNrtzX5cHRWZN5g75kd3qgyTW95jsWP6lZ3kHW8Ylw0W5NbXhh=
W2t_KSg4-t-F1VytdBz1mwq14N5-Pdh9v4w5cW5Jv_F06StSqpW4dRXWW2sjxbHW4cJlhW5ZDdy=
pW8wK-vc837MYhTJDtT8cq8y9Vy3WTS3chDM4W6x3p9b8Sv_DPW8YPPkJ3X4Ph_W8GgKN-9g7jH=
LW8RS36x1kZ4-yW6-fBct7FtHHNW1hHrym32FBLcW3XFkXQ5PkZxqW94kxQH9gSplFW8Dq7pG66=
N7mmW1ktFHP3F9tSRW1L0KKV2SBnTzW4ZKvgQ5Sw9YCMGjhkpL6S15VxtnCm5PFSgDN14Qyb1dV=
9q9N6wp6cGw9vBJW8KyqwV7kwSDfW3V5Dwy8H0DGkN8LJgsXJRvC3N8d9phprHH2Rf5nfSs404"=
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          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
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        </a>
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<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VW=
8N7V58kvW2W1__lNv9fwwkzVNrtzX5cHRWZN5g75kd3qgyTW95jsWP6lZ3nhW5jPqFL84kXb2W2=
VJCBc24ktF7N6Mg2RzJWlb4W9gRBxC93YMj1W5-xMYN2VdyjVW9hDSX_2MtvHJW89WbBc6R7Rn_=
W8mG9fv18Qwn7W31l4LK4N5RhkW7PVh4B58kpbzW6Bg_KF6yXgpvW2G6dgL96CkMwVWwk_b7fPF=
HRW60nbqN2fMG_gW6ZNVYX5mzPcJW9ht7Kf2B4FXMW24-1ks6_Jz5JW7p6Pk13MwSp1W16c-GC4=
7xj3SW88R7T_52KrwjW6TRqfn35L7jsW3NTgXx6j4f18W5Zk_fn49z6hYW6VP5Ty2mTZLXW1jhM=
_x9d1nw_W8FD6T87__zSGW3TR8Fv3694YYW1plXPB3fs7sNN6PwkQclPVFdW8P4Dtc7pDFd6f6X=
1kZY04" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929e=
b2" data-hs-link-id=3D"3" target=3D"_blank">This application note</a> exami=
nes use of the polymer-based reversed-phase resin (PRP-3) for the successfu=
l chromatographic separation of seven key GPCR binding peptides. The condit=
ions and performance characteristics are described as well as the putative =
mechanism underlying isolation. </span></span></p></div></div></td></tr></t=
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