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Subject: Discover the Benefits of GPCR Binding Peptides Isolation
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Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VVytgV3fbMNFW5_4BG=
340kftcW91lZlN5g1l_PN4jRWdq3prCCW95jsWP6lZ3q6W3cPysv4ySMzTN2nl2NmDSj8gW6Ny-=
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2MXVD_W5LqTBB8_R_dJN3-r96vt-6b3W41BgCB2CsQ6sW5nrgDT3W_Tlkf9fYJ7Y04 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/VVytgV3fbMNFW5_4BG340kftcW91lZlN5g1l_PN4jRWdq3prCCW95jsWP6lZ3q6W3cPysv4=
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Q5p45X978NW2XJTkQ6QHXrrW8P2prq40LRflW65MYPX5MBthKW6WXXjF25Q0Z7W49CFXY6MMB1x=
N1kBr-BF9-LQW40RxZ-3WKp14W68DdGH6zyZV3W2TjYj83d3nlJW7Kdy8q7G86VjW76t7gf4yxj=
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_Tlkf9fYJ7Y04 ) examines use of the polymer-based reversed-phase resin (PRP=
-3) for the successful chromatographic separation of seven key GPCR binding=
 peptides. The conditions and performance characteristics are described as =
well as the putative mechanism underlying isolation.

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hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"color: inherit; =
font-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widg=
et" data-hs-cos-type=3D"module"><table class=3D"hse-image-wrapper" role=3D"=
presentation" width=3D"100%" cellpadding=3D"0" cellspacing=3D"0" style=3D"b=
order-spacing:0 !important; border-collapse:collapse; mso-table-lspace:0pt;=
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      <td align=3D"center" valign=3D"top" style=3D"border-collapse:collapse=
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"100%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-=
table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
style=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-famil=
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ding:10px 20px"><div id=3D"hs_cos_wrapper_module_16239611830074" class=3D"h=
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lor: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-genera=
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r=3D"0" cellpadding=3D"0" cellspacing=3D"0" role=3D"presentation" style=3D"=
border-spacing:0 !important; mso-table-lspace:0pt; mso-table-rspace:0pt; bo=
rder-collapse:separate!important">
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=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:Geo=
rgia, serif; font-size:18px; color:#23286b; word-break:break-word; border-r=
adius:20px; cursor:auto; background-color:#D2232B">
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/LT+113/c3tLW04/VVytgV3fbMNFW5_4BG340kftcW91lZlN5g1l_PN4jRWdq3qgyTW95jsWP6l=
Z3nNW9hm8gd1ZKH7dW3_Tyjl2jHPV9W44cYlB7Tsk8nW73g3PF1jMmw2W7HjXPw7RvywfW3ZhRG=
Y6tPCrfW2GFGC382Gs34W3lq09y5k_1dGW4r4hbS4cXRywN8pB3x6KqLLHVv2lxl6J6jnTW5Gk1=
d64XxzTjW1G7N2H8Zl3gzW5V7zBx2z1BvbW8JlZWF689rdNW4QSq1d2f8SbjW4ZVdrG1svz31W8=
vbk6849_TWnW2fLWXl3gD5H8W3fcz1S7P22X_W8WPG7P51g8lkN2QbHhqjvtkhW5zp4zq1V8qnT=
W7fG1Rd3dbNRpW34HZVH2TLHkvN1ypzCTqF1_mW7w4FX880lXgFW8DgTZz3RJwXWN6bXq90MTD_=
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lock" data-hs-link-id=3D"2">
          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
:none;font-style:normal;">Download Application Note</strong>
        </a>
      </td>
    </tr>
  </tbody></table></div></td></tr></tbody></table>
<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VV=
ytgV3fbMNFW5_4BG340kftcW91lZlN5g1l_PN4jRWdq3qgyTW95jsWP6lZ3l8W7TsSdT5z3FbZW=
8t2pth8g2_CjW23wJGM8yLdsSW8wczZz3PC3BGW2kFK8Z2-BMS_W5np8f_1sl5mlN5f2rH2Ms5N=
jV4cxDj7Bq4gbW5lPDZ636kLwtW5nMH5b6ppnvlW5zz0rm7HTSdZW1JsxYW4lRGcBW66lLXl4bF=
JvPW3zM7l-8yNBpSW52N0FK1YvyN8W8B9N7Q4vrgGbW68HWkJ8bgnktVXXPcK5KLdFvW2Kr8T66=
zWDTZN2QylM6yf5G6W7hSGld8bW7bgN86VRNbfXPD-N7wjWZFLYJ60W5gg7Z72p7dnlW5tPrmt1=
w_42NW31B9Yc2xHjQTW91WdbZ7VkfsWW2MTPCD4QyLNQW3pgR0B2GDm3nW1dSCXY1WfRZSf88np=
cv04" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929eb2=
" data-hs-link-id=3D"3" target=3D"_blank">This application note</a> examine=
s use of the polymer-based reversed-phase resin (PRP-3) for the successful =
chromatographic separation of seven key GPCR binding peptides. The conditio=
ns and performance characteristics are described as well as the putative me=
chanism underlying isolation. </span></span></p></div></div></td></tr></tbo=
dy></table>
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