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Subject: Unlock the Secrets of GPCR Binding Peptides
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Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/MWBr0Q-Z2zyW3Kjx4N=
35zn12W6P_DFt5glBtcN9k7MbP3prCCW95jsWP6lZ3n1W5brFmk4DnrKLW8SXGsF89L-DZW8-Jg=
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ysK87MY9TNW4g38m08rFb_YN20rN9BqK_5RW4jHRqT8Jpc36f4Q9FSY04 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/MWBr0Q-Z2zyW3Kjx4N35zn12W6P_DFt5glBtcN9k7MbP3prCCW95jsWP6lZ3n1W5brFmk4D=
nrKLW8SXGsF89L-DZW8-Jg9w6P5TdRW5Wskn92lFbXtW62srCY8kvYX9N5yLjHw993pGV6HlgJ4=
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4MJVM5W43btG65mcXPbW8885Lk6VDnCBW8QXl241mZyC8W34Y5yJ7Vl7hJN8jCDyjHMBlJW1d6p=
4b5Z1szwW44KSpP3y2PT4VR8Rsc7kVT0ZMljKPwW7wP2N67_6q6gC7_zW1Jfz4458yLDFW3tdRD=
1391T4BW66fPLX1H4P6bN5ysK87MY9TNW4g38m08rFb_YN20rN9BqK_5RW4jHRqT8Jpc36f4Q9F=
SY04 ) examines use of the polymer-based reversed-phase resin (PRP-3) for t=
he successful chromatographic separation of seven key GPCR binding peptides=
. The conditions and performance characteristics are described as well as t=
he putative mechanism underlying isolation.

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hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"color: inherit; =
font-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widg=
et" data-hs-cos-type=3D"module"><table class=3D"hse-image-wrapper" role=3D"=
presentation" width=3D"100%" cellpadding=3D"0" cellspacing=3D"0" style=3D"b=
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table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
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rder-collapse:separate!important">
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3lVVN2VjY4hbxFtW8qq5Ss5T0LSVW7vgkTf1q_hgMW4Qs1RY2JSDQvW99Wgcb8dGq_QW3tSn583=
Yz3CmW8b8rNK3rp8y3W1gxvS_7VyCPBM-Ryp_1j1tZW9745Zz71FygrW5flW648-Qg4WW4gSR_6=
7Sz7R6W1wRyWR2mS1ldW4Y7Nf-5s678qW79-6Vh4xp1K9W8C73Nk91RDfnW3s0Xpn6Tk4D6W4f0=
CRy5y9TQzW5ZsJ_f722j6NW7mlwW51-BLGbW4l2MmK41TrVXW6gyhwq7VW4ySW76s-rQ13kGFmN=
56scbxdwNx9W3kYZhB2r92pRW7SQDR08pWT72W6p4TFs2lkbP9W5DLNSv43FrRgW6DXl1-5vSsp=
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          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
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        </a>
      </td>
    </tr>
  </tbody></table></div></td></tr></tbody></table>
<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/MW=
Br0Q-Z2zyW3Kjx4N35zn12W6P_DFt5glBtcN9k7MbP3qgyTW95jsWP6lZ3mrW5G6nVT2n8h3GW3=
NYyf_12DLh0W1FSvKF1pk2-wW831NlX11XPnyN5kcDwW9QmgyW6NzwYq2JXZTgW454njN5GKM3p=
N697k-glCVLbN7K8q_2LZzhnW9lX_GV7KP2rWN4L0dSt1274XM7jpzc6912-VtGXd-5x15TCW21=
Qx5h6sWr22W1bl9dQ5qDsRQW2DhX3983yZV6N307VV13_dJCW5H1MP38krkTKW3nQtDd1C9yH2W=
1pLZxh6HkHL_W8FjXKX1p41mxW3cJ07T4HQKgdW3WqF2F600L99W50cpbR4hB1kVW6tW8pF30Xb=
H3W6Dr_tF2qBzvnW7_rr3S23cQN9W8T1wDC1TSXPsW8CJFWt2nnF0BW5G6J0P7Gx5w1f64gC3g0=
4" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929eb2" d=
ata-hs-link-id=3D"3" target=3D"_blank">This application note</a> examines u=
se of the polymer-based reversed-phase resin (PRP-3) for the successful chr=
omatographic separation of seven key GPCR binding peptides. The conditions =
and performance characteristics are described as well as the putative mecha=
nism underlying isolation. </span></span></p></div></div></td></tr></tbody>=
</table>
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