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Subject: Explore GPCR Peptide Analysis with LabX's New Guide
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M04 )

Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VWRN2x3451KgW8WY6W=
T7708BSW3Jh9SL5gYzVGN4Hzmgg3prCCW95jsWP6lZ3msVGCVn06VC7YVVgSm_v8D4zzhW29xmv=
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W4K0tgh96_mB2N6Drz1f8-QfHW8c0BCL9d8hGcW2FJlyq8sLTC9f75fK4M04 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/VWRN2x3451KgW8WY6WT7708BSW3Jh9SL5gYzVGN4Hzmgg3prCCW95jsWP6lZ3msVGCVn06V=
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5fK4M04 ) examines use of the polymer-based reversed-phase resin (PRP-3) fo=
r the successful chromatographic separation of seven key GPCR binding pepti=
des. The conditions and performance characteristics are described as well a=
s the putative mechanism underlying isolation.

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font-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widg=
et" data-hs-cos-type=3D"module"><table class=3D"hse-image-wrapper" role=3D"=
presentation" width=3D"100%" cellpadding=3D"0" cellspacing=3D"0" style=3D"b=
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"100%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-=
table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
style=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-famil=
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ding:10px 20px"><div id=3D"hs_cos_wrapper_module_16239611830074" class=3D"h=
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lor: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-genera=
l-type=3D"widget" data-hs-cos-type=3D"module"><table align=3D"center" borde=
r=3D"0" cellpadding=3D"0" cellspacing=3D"0" role=3D"presentation" style=3D"=
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rder-collapse:separate!important">
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=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:Geo=
rgia, serif; font-size:18px; color:#23286b; word-break:break-word; border-r=
adius:20px; cursor:auto; background-color:#D2232B">
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/LT+113/c3tLW04/VWRN2x3451KgW8WY6WT7708BSW3Jh9SL5gYzVGN4Hzmgg3qgyTW95jsWP6l=
Z3l5W5wSbSm6-ycWxW6hd6D95s3mkHN17MMFHV0D09W8rpFjr99RqyCW8mVSrw7GzHKyW2wNXF5=
30P-gfW3JLZvW2GdxxNW6mKXxt4RFVYXN6Z_3kjdy9nBW8pDX4H8Flm5ZW6GtYnd3jx5KxW8XZ-=
4R2MYssrW3HcDCv5l2qCJN1l01QTLdjGYW8cpNMZ8bV1_bN8k14jz5GJxLVyXgcb2GQbg5W6VCz=
VH4xpCyZW9gbwkk2_r2H3N5RRxvltQcgBW6Hpf-m6hp--GW706h__6Y2_XvW2Vl0mL3GYLQtW4p=
1pfd45yPWjN6tpDfNsPFrkVvF9WX7xwmfwW1zxmNS3Yyl0CW2WCT6r4XG4GZW2bfkjl7fDqbJW5=
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ight-rule:exactly; font-size:22px; font-family:Arial, sans-serif; Margin:0;=
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k" data-hs-link-id=3D"2">
          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
:none;font-style:normal;">Download Application Note</strong>
        </a>
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  </tbody></table></div></td></tr></tbody></table>
<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VW=
RN2x3451KgW8WY6WT7708BSW3Jh9SL5gYzVGN4Hzmgg3qgyTW95jsWP6lZ3q7W8KSXBF7nnrDkN=
6V3rw96scHCW6Rjdz64m3G6WW1GV93542lSdlN21yJfLgJ_q1W2G14vr3SjCxpW9f201Z6qp-mF=
W3w2p--4pXB_qW1gM0n53XKLTvW97_jdj5DsfVHW8GJGhj1VH6R5W1B5t9h5WVZwHW8HQpfZ8d7=
jWQW2YFM5W8hR843W2xX_N92QTYSgVq32l54DqgmwW2GgHPw6tGWbjW54CY8693-hr2W8LklBH6=
Vyk2HW6HHNpl1XRlY7W2ScBB28WPGbzW53FKB-53hC0hW7Ww7VX42D-NPW4RSMyq8PfT-1W4jKj=
ph8ljbNJW5nDJ5x4rQ1ZJW3yZ0NP2nhmfkW80NVYC18Qxy-W4SJVB91kZZTGW15pv6l2FXn3qd-=
P_Ks04" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929e=
b2" data-hs-link-id=3D"3" target=3D"_blank">This application note</a> exami=
nes use of the polymer-based reversed-phase resin (PRP-3) for the successfu=
l chromatographic separation of seven key GPCR binding peptides. The condit=
ions and performance characteristics are described as well as the putative =
mechanism underlying isolation. </span></span></p></div></div></td></tr></t=
body></table>
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