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Subject: Unlock Peptide Secrets in the GI Tract with LabX
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Download Application Note
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VVvnxc5qjw9nW5YJJs=
5531t8yW2z6fd_5h7nS0N8Vtb8z3prCCW95jsWP6lZ3p0W4Gr_K31FhtPWW599MGK7v1mgXW7Hn=
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sW7W4SKz4vbnt3W2CGK6v2G94Y6W6d-x0k1J5vrNW2G_K5F7Nd04Qf5rSGZb04 )

The benefits of polymer-based reverse-phase resin for isolation of key GPCR=
 binding peptides

The G protein-coupled receptor (GPCR) has shown significance in the develop=
ment of new therapeutic treatments. Analysis of peptides in the gastrointes=
tinal (GI) tract that bind to GPCRs has led to discoveries that relate thes=
e peptides to other functional systems like the endocrine, cardiac, and cen=
tral nervous systems. A key aspect in linking peptide relationships is foun=
d in the purification and identification of peptides in various systems. Is=
olation of these peptides may help identify possible metabolic changes that=
 take place leading to endocrine disorders such as thyroid disease or diabe=
tes, cell proliferation, and kidney disease.

This application note (https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tL=
W04/VVvnxc5qjw9nW5YJJs5531t8yW2z6fd_5h7nS0N8Vtb8z3prCCW95jsWP6lZ3p0W4Gr_K31=
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f5rSGZb04 ) examines use of the polymer-based reversed-phase resin (PRP-3) =
for the successful chromatographic separation of seven key GPCR binding pep=
tides. The conditions and performance characteristics are described as well=
 as the putative mechanism underlying isolation.

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table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" =
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rder-collapse:separate!important">
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=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:Geo=
rgia, serif; font-size:18px; color:#23286b; word-break:break-word; border-r=
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/LT+113/c3tLW04/VVvnxc5qjw9nW5YJJs5531t8yW2z6fd_5h7nS0N8Vtb8z3qgyTW95jsWP6l=
Z3l6W7jl5SH303fkcW46bWSd77zJ-DW4XBMyq1sn-pVW6mcHnG41dlNKW5Fr_wR49JX6FW469pK=
B8lsXf2VRs5YY2l2ky9W3m10632zlD7bMq0j86BgzvXW1RthwQ3-RkwNW4ppDVs4sqFm4W61nwD=
M7Z5PQcW6h4ctG5DMF-hW1xKpV-4F8mywW3k-QDS91HThQN3jD0hJxBzFMW1TYSN85FTyp4W7Zj=
8951LNQH2N2CYXR1MVMCRW80GWcP4T-7HGW2w23BT11PBCtVYfQlp16ZtM2W8QvX8g7YhfyHW5V=
_l7l5wLprzN56nyKMYQGNFW6GCr4T6G_SvCVzwgVl3nSV9cW2BJtb76xky2sW7Wbfk-4D-xvWW7=
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ight-rule:exactly; font-size:22px; font-family:Arial, sans-serif; Margin:0;=
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k" data-hs-link-id=3D"2">
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      </td>
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  </tbody></table></div></td></tr></tbody></table>
<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
pper_type_rich_text" style=3D"color: inherit; font-size: inherit; line-heig=
ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">The benefits of polymer-based reverse-phase resin for isolation =
of key GPCR binding peptides</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">The G protein-coupled receptor (GPCR) has shown significance in the d=
evelopment of new therapeutic treatments. Analysis of peptides in the gastr=
ointestinal (GI) tract that bind to GPCRs has led to discoveries that relat=
e these peptides to other functional systems like the endocrine, cardiac, a=
nd central nervous systems. A key aspect in linking peptide relationships i=
s found in the purification and identification of peptides in various syste=
ms. Isolation of these peptides may help identify possible metabolic change=
s that take place leading to endocrine disorders such as thyroid disease or=
 diabetes, cell proliferation, and kidney disease.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"><a href=3D"https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VV=
vnxc5qjw9nW5YJJs5531t8yW2z6fd_5h7nS0N8Vtb8z3qgyTW95jsWP6lZ3kDN72RT7KLxcrxN1=
432K29bw-yW97Y5Gj6k10RwW6ddGX568M19nW3Y1HPg70qpScW8lt52K7r28B3W2Nb1GH60h0F8=
W6qFLsT70BL22W70Pz4k3PzmwXW1K_bnD5LypFkN1YbZJ6X8_WbW9dfxnL4bb6hHW8KLVnV9580=
lKW6-VMLR6PMhLcW4zjJCm1PvpStV-GFd73btFH0W2tBf8Q6MSdY6W7-LR9v7JwYzfM-yv4pHXW=
pPW61z9hD3Tpqw6W2HjVtr4xF3SzW355CSd3C_5SZW84bhRc2vK9dNW494twn6v4-hqW701mWJ8=
7CtmTW1hkYz-1DG0sTW28Bpgx2lh2hqW61NH3174CS0yW4r85Xp1r447pN1wl8VyV1VD2f5fqy9=
604" rel=3D"noopener" style=3D"mso-line-height-rule:exactly; color:#929eb2"=
 data-hs-link-id=3D"3" target=3D"_blank">This application note</a> examines=
 use of the polymer-based reversed-phase resin (PRP-3) for the successful c=
hromatographic separation of seven key GPCR binding peptides. The condition=
s and performance characteristics are described as well as the putative mec=
hanism underlying isolation. </span></span></p></div></div></td></tr></tbod=
y></table>
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