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Innovative approaches to improve in vivo efficacy

Genetically modified immune cell therapies use cells that have been enginee=
red to improve their abilities to fight cancer, infectious disease, and oth=
er applications. Such approaches have been leveraged to produce T cells, B =
cells, and natural killer cells that express transgenic T cell receptors (T=
CRs), chimeric antigen receptors (CARs), and other enhancements. In the cas=
e of cancer, the goal of this approach is to improve tumor-specific immunog=
enicity and to enhance tumor cell killing.

Despite early successes, there are limitations that complicate the developm=
ent, testing, and manufacturing of TCR-T, CAR-T, and NK cell therapies.

These include:

- Lack of standard potency assays to measure biological activity and effica=
cy
- Suboptimal tumor cell models and difficulties in solid tumor cell targeti=
ng
- Challenges in assessing metabolic status to improve immune cell activitie=
s

This eBook offers important insight into the state of the industry with a f=
ocus on the latest tools and technologies designed to address the challenge=
s of immune cell therapy development and testing.

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00%" style=3D"border-spacing:0 !important; border-collapse:collapse; mso-ta=
ble-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class=3D"hs_padded" st=
yle=3D"border-collapse:collapse; mso-line-height-rule:exactly; font-family:=
Georgia, serif; font-size:18px; color:#23286b; word-break:break-word; paddi=
ng:10px 20px"><div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_=
cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"colo=
r: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-=
type=3D"widget" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_modul=
e_16242852582431_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wra=
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ht: inherit;" data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_=
text"><h1 style=3D"margin:0; mso-line-height-rule:exactly; font-family:Geor=
gia, serif; color:#23286b; font-size:18px; line-height:125%; text-align:cen=
ter" align=3D"center"><span style=3D"color: #000000; font-family: Arial, sa=
ns-serif;">Innovative approaches to improve in vivo efficacy</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
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<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Genetically modified immune cell therapies use cells that have been e=
ngineered to improve their abilities to fight cancer, infectious disease, a=
nd other applications. Such approaches have been leveraged to produce T cel=
ls, B cells, and natural killer cells that express transgenic T cell recept=
ors (TCRs), chimeric antigen receptors (CARs), and other enhancements. In t=
he case of cancer, the goal of this approach is to improve tumor-specific i=
mmunogenicity and to enhance tumor cell killing.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
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<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;"> Despite early successes, there are limitations that complicate the d=
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<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
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<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
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rif;">These include:</span></span></p>
<ul style=3D"mso-line-height-rule:exactly; line-height:175%; list-style-typ=
e:circle">
<li style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%=
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erif;">Lack of standard potency assays to measure biological activity and e=
fficacy</span></span></li>
<li style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%=
"><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-s=
erif;">Suboptimal tumor cell models and difficulties in solid tumor cell ta=
rgeting</span></span></li>
<li style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%=
"><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-s=
erif;">Challenges in assessing metabolic status to improve immune cell acti=
vities</span></span></li>
</ul>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">This eBook offers important insight into the state of the industry wi=
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llenges of immune cell therapy development and testing.</span></span></p></=
div></div></td></tr></tbody></table>
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