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Subject: Explore the Correlation Between CAR T-Cell Activation and Metabolic
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DOWNLOAD APPLICATION NOTE
(https://email.labxmediagroup.com/e3t/Ctc/LT+113/c3tLW04/VWytZY1l46VNN8RMCl=
48n291W1sXT7r5kmrWfMyCDlz5m_5PW5BWr2F6lZ3n_W6rrhGl7H9tl6W8vpwG44dCdgJVn2mpb=
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HzyW89-km96TKCwmN12ZQKXzf5QVf47hxqn04 )

The potential to optimize cell culture media for the ex vivo manufacturing =
of CAR T-cell therapies

Novel reagents for consistent manufacturing of CAR T-cells with well-define=
d phenotypes are needed to improve treatment outcomes in patients. Traditio=
nal ex vivo expansion reagents provide only TCR activation and co-stimulati=
on. Recently developed multi-cytokine backpacks (MCBs) have been shown to p=
rovide CAR T-cell manufacturing with additional cytokine support, critical =
for cell expansion, differentiation, and the selection of potent, long-live=
d phenotypes.

In this application note, we explored different combinations of immunomodul=
ating proteins during creation of a MCB library. The REBEL from 908 Devices=
 was then used to perform AA analysis to assess differences in the metaboli=
c activity in these activated cells.

Download the application note to learn more about REBEL and the ability to =
identify distinct correlations between metabolic activity and CAR T-Cell ac=
tivation and efficacy.

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          <strong style=3D"color:#ffffff;font-weight:normal;text-decoration=
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<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
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; font-size:18px; color:#23286b; word-break:break-word; padding:10px 20px">=
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_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"color: inherit; fo=
nt-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widget=
" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_module_162428525824=
31_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich=
_text" style=3D"color: inherit; font-size: inherit; line-height: inherit;" =
data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_text"><h1 styl=
e=3D"margin:0; mso-line-height-rule:exactly; font-family:Georgia, serif; co=
lor:#23286b; font-size:18px; line-height:125%; text-align:center" align=3D"=
center"><span style=3D"color: #000000; font-family: Arial, sans-serif;">The=
 potential to optimize cell culture media for the ex vivo manufacturing of =
CAR T-cell therapies</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Novel reagents for consistent manufacturing of CAR T-cells with well-=
defined phenotypes are needed to improve treatment outcomes in patients. Tr=
aditional ex vivo expansion reagents provide only TCR activation and co-sti=
mulation. Recently developed multi-cytokine backpacks (MCBs) have been show=
n to provide CAR T-cell manufacturing with additional cytokine support, cri=
tical for cell expansion, differentiation, and the selection of potent, lon=
g-lived phenotypes.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">In this application note, we explored different combinations of immun=
omodulating proteins during creation of a MCB library. The REBEL from 908 D=
evices was then used to perform AA analysis to assess differences in the me=
tabolic activity in these activated cells.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Download the application note to learn more about REBEL and the abili=
ty to identify distinct correlations between metabolic activity and CAR T-C=
ell activation and efficacy.</span></span></p></div></div></td></tr></tbody=
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