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Subject: Enhancing Mass Spectrometry: A Q&A with Dr. Ruotolo
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A conversation with Dr. Brandon Ruotolo, Professor and Associate Chair for =
Research, University of Michigan, Department of Chemistry

Mass spectrometry has a long and celebrated history as a foundational techn=
ique in biochemistry. Its ability to cleave molecules into charged fragment=
s, then sort those fragments according to their mass- to-charge ratio, has =
been harnessed countless times to identify and quantitate a broad range of =
molecules of significant biological interest.

There=E2=80=99s no denying that a tremendous wealth of knowledge has been =
=E2=80=93 and continues to be =E2=80=93 added to our understanding of biomo=
lecular structure and function using these techniques. But occasionally the=
 question arises: Are there ways we could improve, modify, or otherwise twe=
ak this approach to tell us even more, even faster?

Dr. Brandon Ruotolo, professor of chemistry at the University of Michigan, =
and colleagues are looking for ways to make mass spectrometry analysis of m=
acromolecules more quantitative, more nuanced, more information rich, and m=
ore reflective of the contextual reality of biomolecular structure, functio=
n, and interaction.

Download this case study report to learn more. Discussion topics include:

- Native mass spectrometry and the influences of sample preparation and ion=
ization.
- Collision-induced unfolding using Ion Mobility Q-TOF.
- Scale up, meta-analysis, and big data solutions.

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<table role=3D"presentation" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%"><tbody><tr><td class=3D"hs_padded" style=3D"font-family:Georgia, serif=
; font-size:18px; color:#23286b; word-break:break-word; padding:10px 20px">=
<div id=3D"hs_cos_wrapper_module_16242852582431" class=3D"hs_cos_wrapper hs=
_cos_wrapper_widget hs_cos_wrapper_type_module" style=3D"color: inherit; fo=
nt-size: inherit; line-height: inherit;" data-hs-cos-general-type=3D"widget=
" data-hs-cos-type=3D"module"><div id=3D"hs_cos_wrapper_module_162428525824=
31_" class=3D"hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich=
_text" style=3D"color: inherit; font-size: inherit; line-height: inherit;" =
data-hs-cos-general-type=3D"widget" data-hs-cos-type=3D"rich_text"><h1 styl=
e=3D"margin:0; mso-line-height-rule:exactly; font-family:Georgia, serif; co=
lor:#23286b; font-size:18px; line-height:125%; text-align:center" align=3D"=
center"><span style=3D"color: #000000; font-family: Arial, sans-serif;">A c=
onversation with Dr. Brandon Ruotolo, Professor and Associate Chair for Res=
earch, University of Michigan, Department of Chemistry</span></h1>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Mass spectrometry has a long and celebrated history as a foundational=
 technique in biochemistry. Its ability to cleave molecules into charged fr=
agments, then sort those fragments according to their mass- to-charge ratio=
, has been harnessed countless times to identify and quantitate a broad ran=
ge of molecules of significant biological interest.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">There=E2=80=99s no denying that a tremendous wealth of knowledge has =
been =E2=80=93 and continues to be =E2=80=93 added to our understanding of =
biomolecular structure and function using these techniques. But occasionall=
y the question arises: Are there ways we could improve, modify, or otherwis=
e tweak this approach to tell us even more, even faster?</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Dr. Brandon Ruotolo, professor of chemistry at the University of Mich=
igan, and colleagues are looking for ways to make mass spectrometry analysi=
s of macromolecules more quantitative, more nuanced, more information rich,=
 and more reflective of the contextual reality of biomolecular structure, f=
unction, and interaction.</span></span></p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
>&nbsp;</p>
<p style=3D"mso-line-height-rule:exactly; font-size:15px; line-height:125%"=
><span style=3D"color: #000000;"><span style=3D"font-family: Arial, sans-se=
rif;">Download this case study report to learn more. Discussion topics incl=
ude:</span></span></p>
<ul style=3D"mso-line-height-rule:exactly; line-height:175%; list-style-typ=
e:circle">
<li style=3D"font-size: 15px; line-height: 125%;"><span style=3D"color: #00=
0000;"><span style=3D"font-family: Arial, sans-serif;">Native mass spectrom=
etry and the influences of sample preparation and ionization.</span></span>=
</li>
<li style=3D"font-size: 15px; line-height: 125%;"><span style=3D"color: #00=
0000;"><span style=3D"font-family: Arial, sans-serif;">Collision-induced un=
folding using Ion Mobility Q-TOF.</span></span></li>
<li style=3D"font-size: 15px; line-height: 125%;"><span style=3D"color: #00=
0000;"><span style=3D"font-family: Arial, sans-serif;">Scale up, meta-analy=
sis, and big data solutions.</span></span></li>
</ul></div></div></td></tr></tbody></table>
</div>


    
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